Document Detail

Is nicotine depression of neonatal motor behavior exerted through ACTH release?
MedLine Citation:
PMID:  2856807     Owner:  NLM     Status:  MEDLINE    
Prenatal exposure to nicotine tartrate (0.25 mg/kg/pregnant female, gestation days 3 through 21.2x daily IP) markedly decreases ambulatory activity and the number of stop and go movements in 15 day old neonatal rats. Postnatal nicotine tartrate administration alone (0.05 mg/kg SC daily from birth) does not affect these movements nor does it further the motor depression induced by prenatal nicotine treatment. Thus the critical period of neural susceptibility to nicotine appears to be during prenatal life. However, when nicotine is given both pre- and postnatally, horizontal movements are increased in the 15 day old animals, an increase that may be due to inhibition of other types of movement. These alterations in motor behavior are correlated with sharp increases in plasma ACTH levels. As our previous studies [1,25] have shown ACTH to affect neonatal motor behavior, it is suggested that nicotine-evoked ACTH release may mediate some of the motor responses attributed to the drug.
J A King; F L Strand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  9 Suppl 1     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1988  
Date Detail:
Created Date:  1993-06-21     Completed Date:  1993-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Biology Department, New York University, Washington Square, NY 10003.
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MeSH Terms
Adrenocorticotropic Hormone / blood*
Animals, Newborn / blood*
Motor Activity / drug effects*
Nicotine / pharmacology*
Prenatal Exposure Delayed Effects*
Rats, Sprague-Dawley
Reg. No./Substance:
54-11-5/Nicotine; 9002-60-2/Adrenocorticotropic Hormone

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