Document Detail

The niche of stellate cells within rat liver.
MedLine Citation:
PMID:  19725107     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The space of Disse shows analogies to typical stem cell niches comprising of basal lamina components, sympathetic innervation, and adjacent cells that constitute a milieu by paracrine factors and direct physical interactions to retain HSCs at this site and to influence their cellular fate. The space of Disse serves as a niche of stellate cells, which is a novel function of this unique organ structure.
Iris Sawitza; Claus Kordes; Sven Reister; Dieter Häussinger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  50     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2009-12-03     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1617-24     Citation Subset:  IM    
Clinic of Gastroenterology, Hepatology and Infectiology, Heinrich-Heine-University, Düsseldorf, Germany.
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MeSH Terms
Cell Differentiation / physiology*
Cell Movement / physiology*
Chemokine CXCL12 / metabolism
Collagen Type IV / metabolism
Hepatic Stellate Cells / metabolism,  pathology*
Laminin / metabolism
Liver / metabolism,  pathology*
Models, Animal
Rats, Wistar
Receptors, CXCR4 / metabolism
Receptors, Notch / metabolism
Signal Transduction / physiology*
Wnt Proteins / metabolism
Reg. No./Substance:
0/Chemokine CXCL12; 0/Collagen Type IV; 0/Cxcr4 protein, rat; 0/Laminin; 0/Receptors, CXCR4; 0/Receptors, Notch; 0/Wnt Proteins

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