| Influence of pharmacological treatment on blood flow and muscle perfusion in patients with obliterative atheromatosis assessed with isotopic methods. A pilot study. | |
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MedLine Citation:
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PMID: 21119581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Most of the methods don't give the comparison between blood flow at rest and after exercise. Nuclear medicine allows for such assessment and determination of muscle perfusion indexes. The aim of the study was the comparison of the radioisotopic assessment of lower limbs perfusion at rest and after exercise in patients with obliterative atheromatosis subjected to combined treatment with the standard vascular examinations. MATERIAL/METHODS: 35 patients with stage II according to Fontaine and claudication distance 30-500 m, subjected to the combined medical treatment were included to the study. Basic examinations, claudication distance measurements, standard vascular examinations, and radioisotopic examinations of lower limbs perfusion with Tc99mMIBI were performed in all patients. RESULTS: After 6 months of therapy the results of perfusion scintigraphy showed that combined pharmacological treatment caused the significant improvement of calf perfusion at rest (p<0.05), which justifies its application in chronic ischemia of lower limbs. Such improvement was not observed while analyzing the results of standard vascular indexes. CONCLUSIONS: The use of perfusion scintigraphy allows for precise definition of the state of the limbs perfusion and shows the improvement of lower limbs perfusion at rest after medical treatment. It is a more precise and sensitive examination, gives more information comparing to the standard vascular examinations, and completes standard vascular diagnostics in patients with obliterative atheromatosis. |
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Authors:
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Wieslaw Tryniszewski; Dariusz Nowak; Marian Brocki; Zbigniew Maziarz; Jacek Rysz |
Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2011-03-16 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR622-7 Citation Subset: IM |
Affiliation:
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Department of Radiological and Isotopic Diagnostics and Therapy, Medical University of Lodz, Lodz, Poland. wieslaw.tryniszewski@umed.lodz.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Arteriosclerosis Obliterans / drug therapy*, therapy Aspirin / pharmacology, therapeutic use Blood Flow Velocity / drug effects Exercise / physiology* Female Humans Intermittent Claudication / physiopathology* Leg / blood supply* Male Middle Aged Muscle, Skeletal / blood supply*, drug effects Organotechnetium Compounds / metabolism Pentoxifylline / pharmacology, therapeutic use Perfusion Imaging Pilot Projects Pyrrolidines / pharmacology, therapeutic use Regional Blood Flow / drug effects* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Pyrrolidines; 50-78-2/Aspirin; 55837-25-7/buflomedil; 6493-05-6/Pentoxifylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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