| The next generation of positron emission tomography radiopharmaceuticals in oncology. | |
| | |
MedLine Citation:
|
PMID: 21624561 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Although (18)F-fluorodeoxyglucose ((18)F-FDG) is still the most widely used positron emission tomography (PET) radiotracer, there are a few well-known limitations to its use. The last decade has seen the development of new PET probes for in vivo visualization of specific molecular targets, along with important technical advances in the production of positron-emitting radionuclides and their related labeling methods. As such, a broad range of new PET tracers are in preclinical development or have recently entered clinical trials. The topics covered in this review include labeling methods, biological targets, and the most recent preclinical or clinical data of some of the next generation of PET radiopharmaceuticals. This review, which is by no means exhaustive, has been separated into sections related to the PET radionuclide used for radiolabeling: fluorine-18, for the labeling of agents such as FACBC, FDHT, choline, and Galacto-RGD; carbon-11, for the labeling of choline; gallium-68, for the labeling of peptides such as DOTATOC and bombesin analogs; and the long-lived radionuclides iodine-124 and zirconium-89 for the labeling of monoclonal antibodies cG250, and J591 and trastuzumab, respectively. |
| | |
Authors:
|
Samuel L Rice; Celeste A Roney; Pierre Daumar; Jason S Lewis |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Seminars in nuclear medicine Volume: 41 ISSN: 1558-4623 ISO Abbreviation: Semin Nucl Med Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1264464 Medline TA: Semin Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 265-82 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Radiochemistry Service, Department of Radiology and Program in Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A broad overview of positron emission tomography radiopharmaceuticals and clinical applications: wha...
Next Document: Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid.