| A newly identified gene cluster in Aspergillus nidulans comprises five novel genes localized in the alc region that are controlled both by the specific transactivator AlcR and the general carbon-catabolite repressor CreA. | |
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MedLine Citation:
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PMID: 8736527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethanol-utilization in Aspergillus nidulans is mediated by alcohol dehydrogenase I and aldehyde dehydrogenase encoded by alcA and aldA, respectively. Both genes are under the transcriptional control of the specific activator AlcR and the general carbon catabolite repressor CreA. The alcR and alcA genes are closely linked in chromosome VII; aldA is located in chromosome VIII. We have identified five other transcripts that are expressed from the same genomic region as alcA and alcR. They are inducible by the gratuitous inducer ethyl methyl ketone (EMK), and are carbon catabolite repressed. The corresponding genes, designated alcM, alcS, alcO, alcP, and alcU, are differentially regulated by the specific transcriptional activator AlcR, and they are not all under the direct control by the CreA repressor. Some of the inducible transcripts are very abundant in the cell, whereas others are poorly expressed. Two sets of genes, alcM/alcS and alcR/alcO, are divergently transcribed and probably share a common cis-acting region, whereas alcP and alcU are individually transcribed from the same strand as alcA and alcR, and have their own promoters. The significance of the alc gene clustering is discussed. At least four of the five novel alc genes in the cluster are not essential for ethanol metabolism. |
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Authors:
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S Fillinger; B Felenbok |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular microbiology Volume: 20 ISSN: 0950-382X ISO Abbreviation: Mol. Microbiol. Publication Date: 1996 May |
Date Detail:
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Created Date: 1997-02-03 Completed Date: 1997-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8712028 Medline TA: Mol Microbiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 475-88 Citation Subset: IM |
Affiliation:
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Institut de Génétique et Microbiologie, Université Paris-Sud, URA CNRS 1354, Centre d'Orsay, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aspergillus nidulans
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genetics*,
growth & development,
metabolism Carbon / metabolism* DNA-Binding Proteins / metabolism* Ethanol / metabolism Fungal Proteins / metabolism* Gene Expression Genes, Fungal* Multigene Family* RNA, Fungal RNA, Messenger Repressor Proteins / metabolism* Sequence Deletion Trans-Activators / metabolism* Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/ALCR protein, Aspergillus nidulans; 0/DNA-Binding Proteins; 0/Fungal Proteins; 0/RNA, Fungal; 0/RNA, Messenger; 0/Repressor Proteins; 0/Trans-Activators; 144516-87-0/CreA protein, Aspergillus nidulans; 64-17-5/Ethanol; 7440-44-0/Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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