Document Detail

A newly developed porcine heart valve bioprosthesis fixed with an epoxy compound. An experimental evaluation.
MedLine Citation:
PMID:  8003758     Owner:  NLM     Status:  MEDLINE    
Concerns with currently available bioprostheses are calcification, long-term durability, and functional and hemodynamic performance. It has been well known that these concerns are all more or less related to the fixatives, glutaraldehyde or formaldehyde, used in preserving bioprostheses. To address these concerns, we undertook the development of a porcine bioprosthesis fixed with an epoxy compound. It was discovered that the porcine leaflets fixed with the epoxy compound appeared more natural than those preserved with glutaraldehyde. The performance of this newly developed epoxy compound bioprosthesis (three samples) was evaluated in a juvenile sheep model. The results were compared to those of its glutaraldehyde counterpart (three samples). Two-dimensional echocardiographic inspection of the valvular leaflet motion indicated that the epoxy compound leaflets were more pliable than their glutaraldehyde counterparts. In addition, the epoxy compound valve appeared to open more widely than the glutaraldehyde valve. Color Doppler flow mapping demonstrated that the blood flow distal to the epoxy compound valve was slightly broader than that observed distal to the glutaraldehyde valve. Moreover, at retrieval, less calcium and pannus ingrowth were observed in the epoxy compound valve than its glutaraldehyde counterpart. The results of this preliminary evaluation indicated that the performance of this newly developed epoxy compound valve was at least equivalent to its glutaraldehyde counterpart, if not better.
H W Sung; R Tu; S H Shen; T H Witzel; D Lin; C Hata; C J Kingsbury; Y Noishiki; Y Tomizawa; R C Quijano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  40     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1994 Apr-Jun
Date Detail:
Created Date:  1994-07-18     Completed Date:  1994-07-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  192-8     Citation Subset:  IM    
Department of Chemical Engineering, National Center University, Taoyuan, Taiwan, Republic of China.
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MeSH Terms
Biocompatible Materials*
Echocardiography, Doppler
Epoxy Compounds*
Heart Valve Prosthesis*
Heart Valves / ultrasonography
Hemodynamics / physiology
Prosthesis Design
Pulsatile Flow
Reg. No./Substance:
0/Biocompatible Materials; 0/Epoxy Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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