Document Detail


A newly characterized HLA DQ beta allele associated with pemphigus vulgaris.
MedLine Citation:
PMID:  2894075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individuals having an allele associated with susceptibility develop disease. The identification of allelic variants more precisely correlated with disease susceptibility would greatly facilitate clinical screening and diagnosis. Oligonucleotide-primed gene amplification in vitro was used to determine the nucleotide sequence of a class II variant found almost exclusively in patients with the autoimmune skin disease pemphigus vulgaris. In addition to clinical implications, the disease-restricted distribution of this variant should provide insight into the molecular mechanisms underlying associations between diseases and HLA-class II genes.
Authors:
A A Sinha; C Brautbar; F Szafer; A Friedmann; E Tzfoni; J A Todd; L Steinman; H O McDevitt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  239     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-29     Completed Date:  1988-03-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1026-9     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, Stanford University, CA 94305.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M19239;  M21135
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MeSH Terms
Descriptor/Qualifier:
Alleles
Autoimmune Diseases / genetics*,  immunology
Base Sequence
DNA / genetics
Gene Amplification
Genetic Variation
HLA-D Antigens / genetics*
HLA-DQ Antigens / genetics*,  immunology
HLA-DR Antigens / immunology
Humans
Molecular Sequence Data
Nucleic Acid Hybridization
Pemphigus / genetics*,  immunology
Polymorphism, Restriction Fragment Length
Chemical
Reg. No./Substance:
0/HLA-D Antigens; 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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