| A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. | |
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MedLine Citation:
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PMID: 2894075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The inheritance of particular alleles of major histocompatibility complex class II genes increases the risk for various human autoimmune diseases; however, only a small percentage of individuals having an allele associated with susceptibility develop disease. The identification of allelic variants more precisely correlated with disease susceptibility would greatly facilitate clinical screening and diagnosis. Oligonucleotide-primed gene amplification in vitro was used to determine the nucleotide sequence of a class II variant found almost exclusively in patients with the autoimmune skin disease pemphigus vulgaris. In addition to clinical implications, the disease-restricted distribution of this variant should provide insight into the molecular mechanisms underlying associations between diseases and HLA-class II genes. |
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Authors:
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A A Sinha; C Brautbar; F Szafer; A Friedmann; E Tzfoni; J A Todd; L Steinman; H O McDevitt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 239 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-29 Completed Date: 1988-03-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1026-9 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, Stanford University, CA 94305. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/M19239; M21135 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Autoimmune Diseases / genetics*, immunology Base Sequence DNA / genetics Gene Amplification Genetic Variation HLA-D Antigens / genetics* HLA-DQ Antigens / genetics*, immunology HLA-DR Antigens / immunology Humans Molecular Sequence Data Nucleic Acid Hybridization Pemphigus / genetics*, immunology Polymorphism, Restriction Fragment Length |
| Chemical | |
Reg. No./Substance:
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0/HLA-D Antigens; 0/HLA-DQ Antigens; 0/HLA-DR Antigens; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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