Document Detail

A new variant of interaction between phospholipid antibodies and the protein C system.
MedLine Citation:
PMID:  8180337     Owner:  NLM     Status:  MEDLINE    
The influence of 38 IgG fractions with either cardiolipin antibodies only (CLa) or both CLa and lupus anticoagulant activity (LA) on the response to activated protein C (APC) and on the snake venom activation of protein C were investigated. Five of eight IgG fractions with LA activity showed a tendency to reduce the effect of APC in the aPTT method and to simulate the APC-resistance phenomenon. This effect was not observed in IgG fractions without LA activity. The addition of IgG fractions did not decrease enzymatic activation of protein C in normal plasma. No correlation was found between sample protein C activity and CLa level or the extent of clotting time prolongation. These observations suggested that acquired resistance to APC in the presence of some types of phospholipid antibodies may be a cause of thrombophilia in such patients.
M I Bokarewa; M Blombäck; N Egberg; S Rosén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  5     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-10     Completed Date:  1994-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  37-41     Citation Subset:  IM    
Department of Laboratory Medicine and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Antibodies, Anticardiolipin / pharmacology
Antibodies, Antiphospholipid / pharmacology*
Chromatography, Gel
Enzyme Activation
Immunoglobulin G / pharmacology
Lupus Coagulation Inhibitor / pharmacology
Middle Aged
Protein C / metabolism*
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antibodies, Antiphospholipid; 0/Immunoglobulin G; 0/Lupus Coagulation Inhibitor; 0/Protein C

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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