| A new triterpene from the plant of uncaria macrophylla. | |
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MedLine Citation:
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PMID: 22222909 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Our ongoing investigations on the stem bark of Uncaria macrophylla afforded a new ursolic triterpene, 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester (1), named uncariursanic acid, and three known ursolic triterpenes including 3β,6β,19α-trihydroxy-23-oxo-urs-12-en-28-oic acid (2), 3β,6β,19α-trihydroxy-urs-12-en-28-oic acid (3) and ursolic acid (4). Their structures were elucidated by extensive spectral methods, including 1D and 2D NMR and HR-ESI-MS. The cytotoxicities of the four compounds were evaluated against two cancer cell lines (MCF-7 and HepG2) by the MTT method, and only compound 4 exhibited potent activity. |
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Authors:
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Guangli Sun; Xiaopo Zhang; Xudong Xu; Junshan Yang; Mingliang Zhong; Jingquan Yuan |
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Publication Detail:
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Type: Journal Article Date: 2012-01-05 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 17 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 504-10 Citation Subset: IM |
Affiliation:
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Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. xdxu@implad.ac.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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