| A new transmyocardial degradable stent combined with growth factor, heparin, and stem cells in acute myocardial infarction. | |
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MedLine Citation:
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PMID: 19578069 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS: We developed a new method-transmyocardial drilling revascularization (TMDR) with absorbable stent incorporated with basic fibroblast growth factor (bFGF) and heparin. The present study tested the effect of this method with transplantation of bone marrow-derived stem cells (BMSCs) in acute myocardial infarction. METHODS AND RESULTS: Infarction was produced in mini-swine by ligating the left anterior descending (LAD) coronary artery. TMDR of 3.0 mm in diameter was made by mechanical drilling in the infarcted area. The animals that had LAD ligation were divided into six groups according to the procedures followed (n = 6 in each): control; T (TMDR); C (cell implantation); TS (TMDR+stent implantation); TC (TMDR+cell implantation); TSC (TMDR+stent implantation+cell implantation). Left ventricular (LV) function, myocardial perfusion, vascular density, and histological and morphological analyses were evaluated pre-operatively and at 30 min and 6 weeks post-operatively. Six weeks after operation, the above indices were significantly better in the TSC group than in other groups (P < 0.001 compared with the control group, and P < 0.05 or 0.01 compared with the TS and TC groups), although TS and TC also showed better results than the control group (P < 0.05). CONCLUSION: We have demonstrated in a pig model that an intramyocardial stent implanted with slow release of bFGF, heparin, and BMSC transplantation may significantly increase LV function, cardiac blood flow, and vascular density. Therefore, the present study may provide a new method for the surgical treatment of myocardial infarction. |
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Authors:
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Ying Wang; Xiao-Cheng Liu; Guang-Wei Zhang; Jian Zhao; Jie-Min Zhang; Rong-Fang Shi; Yun-Zhou Huang; Chun-Hua Zhao; Tian-Jun Liu; Cun-Xian Song; Feng Lü; Qin Yang; Guo-Wei He |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-03 |
Journal Detail:
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Title: Cardiovascular research Volume: 84 ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: England |
Other Details:
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Languages: eng Pagination: 461-9 Citation Subset: IM |
Affiliation:
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Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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