Document Detail

A new tool for the validation of umbilical cord acid-base data.
MedLine Citation:
PMID:  20840525     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify the distribution of carbon dioxide tension (pCO(2) ) relative to pH in validated umbilical cord acid-base data.
DESIGN: Observational study.
SETTING: European hospital labour wards.
POPULATION: Data for 36,432 term newborns were obtained from three sources: two trials of fetal monitoring with electrocardiography (ECG; the Swedish randomised controlled trial and the European Union Fetal ECG trial) and data from Mölndal Hospital.
METHODS: From the total study population, cases with missing values or obvious typing errors were excluded. The remaining data were validated based on specified criteria. Percentiles of arterial pCO(2) by pH were calculated using multilevel regression modelling.
MAIN OUTCOME MEASURES: Umbilical cord pH, pCO(2) and base deficit.
RESULTS: Acid-base values were considered invalid in one out of seven cases. Percentiles for arterial pCO(2) corresponding to specified values of arterial pH were developed from the validated data of 26, 690 cases.
CONCLUSIONS: Percentiles for arterial pCO(2) for a specified arterial pH can be used as a tool to identify cases with erroneously low pCO(2) values, and thus avoid an incorrect interpretation of the newborn's acid-base status.
G A B Kro; B M Yli; S Rasmussen; H Norèn; I Amer-Wåhlin; O D Saugstad; B Stray-Pedersen; K G Rosén
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2010-09-14
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  117     ISSN:  1471-0528     ISO Abbreviation:  BJOG     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  1544-52     Citation Subset:  AIM; IM    
Copyright Information:
© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.
Department of Paediatric Research, Women and Children's Division, Oslo University Hospital Rikshospitalet, Oslo, Norway.
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MeSH Terms
Acid-Base Equilibrium / physiology*
Acid-Base Imbalance / diagnosis
Carbon Dioxide / blood*
Fetal Blood / chemistry*
Hydrogen-Ion Concentration
Infant, Newborn
Multicenter Studies as Topic
Partial Pressure
Randomized Controlled Trials as Topic
Umbilical Arteries / chemistry*
Umbilical Veins / chemistry*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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