| A new tool for the validation of umbilical cord acid-base data. | |
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MedLine Citation:
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PMID: 20840525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To identify the distribution of carbon dioxide tension (pCO(2) ) relative to pH in validated umbilical cord acid-base data. DESIGN: Observational study. SETTING: European hospital labour wards. POPULATION: Data for 36,432 term newborns were obtained from three sources: two trials of fetal monitoring with electrocardiography (ECG; the Swedish randomised controlled trial and the European Union Fetal ECG trial) and data from Mölndal Hospital. METHODS: From the total study population, cases with missing values or obvious typing errors were excluded. The remaining data were validated based on specified criteria. Percentiles of arterial pCO(2) by pH were calculated using multilevel regression modelling. MAIN OUTCOME MEASURES: Umbilical cord pH, pCO(2) and base deficit. RESULTS: Acid-base values were considered invalid in one out of seven cases. Percentiles for arterial pCO(2) corresponding to specified values of arterial pH were developed from the validated data of 26, 690 cases. CONCLUSIONS: Percentiles for arterial pCO(2) for a specified arterial pH can be used as a tool to identify cases with erroneously low pCO(2) values, and thus avoid an incorrect interpretation of the newborn's acid-base status. |
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Authors:
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G A B Kro; B M Yli; S Rasmussen; H Norèn; I Amer-Wåhlin; O D Saugstad; B Stray-Pedersen; K G Rosén |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Validation Studies Date: 2010-09-14 |
Journal Detail:
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Title: BJOG : an international journal of obstetrics and gynaecology Volume: 117 ISSN: 1471-0528 ISO Abbreviation: BJOG Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-12 Completed Date: 2010-12-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100935741 Medline TA: BJOG Country: England |
Other Details:
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Languages: eng Pagination: 1544-52 Citation Subset: AIM; IM |
Copyright Information:
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© 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology. |
Affiliation:
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Department of Paediatric Research, Women and Children's Division, Oslo University Hospital Rikshospitalet, Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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physiology* Acid-Base Imbalance / diagnosis Carbon Dioxide / blood* Fetal Blood / chemistry* Humans Hydrogen-Ion Concentration Infant, Newborn Multicenter Studies as Topic Partial Pressure Randomized Controlled Trials as Topic Umbilical Arteries / chemistry* Umbilical Veins / chemistry* |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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