| A new tool for photoaffinity labeling studies: a partially constrained, benzophenone based, alpha-amino acid. | |
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MedLine Citation:
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PMID: 20505870 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The novel alpha-amino acid BpAib, a partially conformationally restricted analogue of the currently extensively used 3-(4-benzoylphenyl)alanine (Bpa) photoaffinity label, was synthesized, optically resolved, fully characterized, and appropriately derivatized. An intermolecular photocrosslinking experiment highlighted its regioselective reactivity towards the S-methyl side-chain group of a Met-based dipeptide, which is closely comparable to that of Bpa. |
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Authors:
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Karen Wright; Alessandro Moretto; Marco Crisma; Michel Wakselman; Jean-Paul Mazaleyrat; Fernando Formaggio; Claudio Toniolo |
Publication Detail:
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Type: Journal Article Date: 2010-05-26 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 8 ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-06 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 3281-6 Citation Subset: IM |
Affiliation:
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ILV, UMR CNRS 8180, University of Versailles, 78035 Versailles, France. wright@chimie.uvsq.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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chemical synthesis*,
chemistry* Benzophenones / chemistry* Photoaffinity Labels / chemical synthesis*, chemistry* Photochemical Processes Spectrum Analysis |
| Chemical | |
Reg. No./Substance:
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0/Benzophenones; 0/Photoaffinity Labels; 119-61-9/benzophenone; 56-41-7/Alanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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