Document Detail

A new therapeutic approach to the fetus with congenital complete heart block: preemptive, targeted therapy with dexamethasone.
MedLine Citation:
PMID:  9764666     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Therapy of established congenital complete heart block in the fetus has resulted in improved survival but persistence of heart block. This exposes the infant to the morbidity of heart block, including the risk of sudden death and pacemaker implantation. CASE: A 35-year-old gravida 2, para 1, with Sjogren syndrome and a previous pregnancy complicated by congenital complete heart block presented during her second pregnancy. Intensive fetal monitoring with echocardiography was employed. Early evidence of myocardial dysfunction and dysrhythmia was found, dexamethasone therapy was initiated, and the dysfunction and dysrhythmia resolved. The pregnancy went to term without further complication. CONCLUSION: This represents a new and successful strategy to identify very early signs of myocardial disease in a fetus at high risk of congenital complete heart block, enabling targeted, preemptive therapy.
D Rosenthal; M Druzin; C Chin; A Dubin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  92     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-02     Completed Date:  1998-11-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-91     Citation Subset:  AIM; IM    
Department of Pediatric Cardiology, Stanford University Medical School, California 94304, USA.
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MeSH Terms
Dexamethasone / therapeutic use*
Fetal Diseases / prevention & control*
Heart Block / congenital*,  prevention & control*
Pregnancy Complications, Cardiovascular*
Reg. No./Substance:

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