Document Detail


A new therapeutic approach to the fetus with congenital complete heart block: preemptive, targeted therapy with dexamethasone.
MedLine Citation:
PMID:  9764666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Therapy of established congenital complete heart block in the fetus has resulted in improved survival but persistence of heart block. This exposes the infant to the morbidity of heart block, including the risk of sudden death and pacemaker implantation. CASE: A 35-year-old gravida 2, para 1, with Sjogren syndrome and a previous pregnancy complicated by congenital complete heart block presented during her second pregnancy. Intensive fetal monitoring with echocardiography was employed. Early evidence of myocardial dysfunction and dysrhythmia was found, dexamethasone therapy was initiated, and the dysfunction and dysrhythmia resolved. The pregnancy went to term without further complication. CONCLUSION: This represents a new and successful strategy to identify very early signs of myocardial disease in a fetus at high risk of congenital complete heart block, enabling targeted, preemptive therapy.
Authors:
D Rosenthal; M Druzin; C Chin; A Dubin
Related Documents :
15026836 - Fetal heart rate variability due to vibroacoustic stimulation: linear and nonlinear con...
2681826 - First trimester bradycardia. a sign of impending fetal loss.
16113556 - Effect of betamethasone administration on fetal heart rate tracing: a blinded longitudi...
18467806 - Peripartum cardiomyopathy.
16727116 - Embryo loss following gnrh-induced ovulation in anovulatory mares.
25041946 - Elastography in predicting preterm delivery in asymptomatic, low-risk women: a prospect...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  92     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-02     Completed Date:  1998-11-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  689-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatric Cardiology, Stanford University Medical School, California 94304, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Dexamethasone / therapeutic use*
Female
Fetal Diseases / prevention & control*
Heart Block / congenital*,  prevention & control*
Humans
Pregnancy
Pregnancy Complications, Cardiovascular*
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Unconjugated estriol as an indication for prenatal diagnosis of steroid sulfatase deficiency by in s...
Next Document:  Magnesium sulfate, maternal hypothermia, and fetal bradycardia with loss of heart rate variability.