| A new technique of coronary artery ligation: experimental myocardial infarction in rats in vivo with reduced mortality. | |
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MedLine Citation:
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PMID: 9406166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo models of myocardial infarction following coronary artery ligation in the rat still suffer from high early mortality and a low rate of success of myocardial infarction. This study investigated the possibility of reducing early mortality and increasing the rate of myocardial infarction by modifications of surgical techniques. Eighteen rats were divided into two groups: normal control (3 rats) and ligation (15 rats). The major modifications of surgical techniques used in this study include: (1) no exteriorization of the heart, (2) ligation of the origins of the branches rather than the main trunk of the left coronary artery, (3) removal of air from the chest after closure, (4) supplying oxygen immediately after extubation. Following surgery, the rats recovered uneventfully and 11 rats were alive after 16 weeks. One rat, with a large myocardial infarction, died 2 h after surgery. Early mortality (during surgery and 1 week after surgery) was 6.7% with a success rate of myocardial infarction of 85%. The left ventricle in the ligation group showed significant dilation relative to normal and sham-operated control hearts (317% of control hearts, p < 0.001). However, myocardial mass did not increase. The average infarct size was 33%. These results demonstrate that a reduction in early mortality and an increased success rate of myocardial infarction can be achieved by modifications of surgical techniques. |
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Authors:
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J Ye; L Yang; R Sethi; J Copps; B Ramjiawan; R Summers; R Deslauriers |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 176 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-01-23 Completed Date: 1998-01-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 227-33 Citation Subset: IM |
Affiliation:
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Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Manitoba, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Cardiac Surgical Procedures / methods* Coronary Circulation Coronary Disease / pathology, physiopathology* Female Heart Ventricles / pathology, physiopathology Ligation / methods, mortality Male Myocardial Infarction / pathology, physiopathology* Rats Rats, Sprague-Dawley Survival Rate Ventricular Function, Left / physiology |
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