Document Detail


A new technique for the analysis of phasic gastric acid responses in the unanesthetized rat.
MedLine Citation:
PMID:  7421114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A chronically indwelling gastric fistula was implanted into rats. To collect gastric acid, a collection system was coupled to the fistula. This system operated by infusing physiological saline directly into the stomach of unanesthetized rats; the acid content of the perfusate was immediately determined by automatic titration machinery. Using this technique, a value of 3.25 uEq H+/2 minutes was obtained as the basal gastric secretion. For a sham-fed test meal of 2 ml of 36% sucrose, the stimulated phase of gastric acid secretion consisted of a dynamic response (peak 200% of basal) with a brief latency (< 2 minutes) and short duration (< 24 minutes). Results indicated that this response to sham feeding was a cephalic response, since direct infusion of a similar test meal into the stomach did not alter basal gastric acid output. Experience with the perfusion-collection technique indicated that the procedure was a sensitive nondisruptive method for chronic gastric acid collection from unanesthetized animals.
Authors:
H P Weingarten; T L Powley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory animal science     Volume:  30     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Eating
Gastric Acid / secretion*
Gastric Acidity Determination / methods,  veterinary*
Gastric Fistula
Male
Perfusion
Rats / physiology*
Sucrose / administration & dosage
Grant Support
ID/Acronym/Agency:
AM00363/AM/NIADDK NIH HHS; AM15511/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
57-50-1/Sucrose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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