| A new system to target the effect-site during propofol sedation. | |
| | |
MedLine Citation:
|
PMID: 12904185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: We evaluated a new, integrated, covariate-adjusted, target-controlled infusion system during sedation with propofol combined with 50% nitrous oxide (N2O) and with propofol only (Air). METHODS: The protocol consisted of sequential 15-minute cycles in 20 volunteers. After a 15-minute control period, propofol was infused to an initial target effect-site concentration of 0.25 microg x ml-1 (N2O) or 1.5 microg x ml-1 (Air). Subsequently, the target effect-site concentration was increased by 0.25 (N2O) or 0.5 microg x ml-1 (Air) for 15 min This sequence was continued until the volunteers lost consciousness as defined by an Observer's Assessment Alertness/Sedation (OAA/S) score = 2. RESULTS: Venous plasma propofol concentrations at the beginning(9 elapsed minutes) and end(15 elapsed minutes) of the pseudo-steady state period differed by only 0.00 +/- 0.16 microg x ml-1 (P = 0.78) during the N2O and 0.00 +/- 0.25 microg x ml-1 (P = 0.91) during the Air trial. OAA/S scores and bispectral index values, as surrogate measures of pharmacodynamic effect, were not different during this time in either trial. The median(25th, 75th percentiles) of the median performance error (%) was -13 (-24, -1) during the N2O and -18 (-26, -9) during the Air trial. The median absolute performance error (%) was 17 (10, 24) in the N2O and 22 (12, 28) in Air trial. The divergence (%/h) was -10 (-26, 4) in the N2O and 14 (-21, 26) in Air trial. The wobble was 7 (5, 10) in the N2O and 6 (4, 8) in the Air trial. CONCLUSIONS: When tested with venous blood samples, our TCI system for propofol, using a covariate-adjusted, integrated pharmacokinetic model to target effect-site concentrations, demonstrated a clinically acceptable accuracy and stability during mild to moderate sedation. |
| | |
Authors:
|
A G Doufas; M Bakhshandeh; A R Bjorksten; R Greif; D I Sessler |
Related Documents
:
|
21762835 - Symptoms of delirium: an exploratory factor analytic study among referred patients. 10866905 - A comparison of remifentanil and fentanyl in patients undergoing surgery for intracrani... 1286495 - Reversal of central nervous system effects by flumazenil after intravenous conscious se... 9818105 - Improved postoperative analgesia with isoflurane than with propofol anaesthesia. 17112835 - Additional effect of hyperparathyroidism on inflammatory status and rhuepo requirements... 16670045 - Adjunctive treatment of acute mania with risperidone versus typical antipsychotics: a r... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Acta anaesthesiologica Scandinavica Volume: 47 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-08-07 Completed Date: 2004-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: Denmark |
Other Details:
|
Languages: eng Pagination: 944-50 Citation Subset: IM |
Affiliation:
|
OUTCOMES RESEARCH Institute and Department of Anesthesiology and Pharmacology, University of Louisville, Louisville, KY 40202, USA. agdoufas@louisville.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Electroencephalography / drug effects Female Humans Hypnotics and Sedatives / administration & dosage* Male Propofol / administration & dosage*, blood, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Hypnotics and Sedatives; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relaxing intraoperative natural sound blunts haemodynamic change at the emergence from propofol gene...
Next Document: Automated responsiveness test and bispectral index monitoring during propofol and propofol/N2O sedat...