Document Detail


A new system for the metabolic investigation of the isolated, perfused rat heart.
MedLine Citation:
PMID:  10775489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
NMR spectroscopy is an invaluable technique in metabolic investigations of isolated, perfused hearts. Most studies employ global perfusion methods together with an NMR coil that surrounds the heart and thus detects signals from its entirety. The present report describes the construction and testing of a novel, two surface-coil probe, in combination with a dual-perfused heart preparation, that enables spectra to be collected independently from the two coronary beds of the rat heart.(31)P NMR spectra of perfused rat hearts in which the septum and right ventricle have been made ischaemic, while the free left ventricular wall is fully perfused, demonstrate the powerful potential of this new system.
Authors:
P B Garlick; H G Parkes; A C Cave
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  32     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-08-11     Completed Date:  2000-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  853-8     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Department of Radiological Sciences, Guy's Hospital, London, SE1 9RT, UK. pamela.garlick@kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Heart
Male
Myocardial Ischemia / metabolism
Myocardium / metabolism*
Nuclear Magnetic Resonance, Biomolecular / methods*
Rats
Rats, Wistar

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