Document Detail

A new strategy for the reduction of acute myocardial infarction in variant angina.
MedLine Citation:
PMID:  1835559     Owner:  NLM     Status:  MEDLINE    
To study the effects of stepwise early treatment in variant angina pectoris, frequencies of cardiac events and complications were examined after three different types of treatment. The subjects of the study consisted of 159 consecutive patients with variant angina pectoris, who were in need of hospitalization. The three treatment modalities were the introduction of calcium antagonists, nicorandil and nitroglycerin infusion, and percutaneous transluminal coronary angioplasty (PTCA), respectively. The cardiac event rate for this series of patients was 16% (25 of 159). The cumulative cardiac event rate was 22% at 1 year and 23% at 3 years in the first treatment period; 11% at the same intervals in the second treatment period; and 6% at the same intervals in the third treatment period. Our results suggest that it is important in the treatment of variant angina pectoris not only to prevent anginal attacks by the use of fast-acting coronary vasodilators, but also to initiate early revascularization.
H Kishida; Y Tada; Y Tetsuoh; Y Yamazaki; T Saito; N Fukuma; N Hata; M Yasutake; H Hayakawa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  122     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1991-12-31     Completed Date:  1991-12-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1554-61     Citation Subset:  AIM; IM    
Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Angina Pectoris, Variant / complications*,  epidemiology,  therapy
Angioplasty, Transluminal, Percutaneous Coronary
Calcium Channel Blockers / therapeutic use
Coronary Angiography
Drug Therapy, Combination
Evaluation Studies as Topic
Middle Aged
Myocardial Infarction / epidemiology,  etiology,  prevention & control*
Niacinamide / administration & dosage,  analogs & derivatives
Nitroglycerin / administration & dosage
Regression Analysis
Retrospective Studies
Vasodilator Agents / administration & dosage
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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