Document Detail


A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization.
MedLine Citation:
PMID:  7191847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new sesquiterpene antibiotic, heptelidic acid, was found in the culture filtrate of three different strains of fungi isolated from soil samples. These strains were identified as Gliocladium virens, Chaetomium globosum and Trichoderma viride. Heptelidic acid was produced by conventional submerged culture and purified by successive column chromatography on silica gel and Sephadex LH-20 and finally by preparative TLC on silica gel. The molecular formula of heptelidic acid was determined as C15H20O5 on the basis of elementary analysis and high resolution mass spectrometry of its monomethyl ester. The antimicrobial spectrum of the antibiotic revealed its specific activity against anaerobic bacteria, especially against Bacteroides fragilis.
Authors:
Y Itoh; K Kodama; K Furuya; S Takahashi; T Haneishi; Y Takiguchi; M Arai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  33     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1980 May 
Date Detail:
Created Date:  1981-01-16     Completed Date:  1981-01-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  468-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / biosynthesis*,  pharmacology
Ascomycota / isolation & purification*
Bacteria / drug effects
Chaetomium / isolation & purification*,  metabolism
Chemical Phenomena
Chemistry
Chemistry, Physical
Drug Resistance, Microbial
Fermentation
Fungi / drug effects
Mice
Mitosporic Fungi / isolation & purification*,  metabolism
Physicochemical Phenomena
Sesquiterpenes / biosynthesis,  pharmacology
Trichoderma / isolation & purification*,  metabolism
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Sesquiterpenes; 57710-57-3/heptelidic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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