| The new role of calcimimetics as vasculotropic agents. | |
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MedLine Citation:
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PMID: 19092812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The discovery of the calcium-sensing receptor (CaSR) and the development of calcimimetics have provided new insights into calcium homeostasis and new therapeutic opportunities for parathyroid-related disorders. However, the CaSR is also implicated in various other cellular processes, and the translational applications of calcimimetics may not be exclusively calcium-centric. Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology. |
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Authors:
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Ziyad Al-Aly |
Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Kidney international Volume: 75 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-18 Completed Date: 2009-02-09 Revised Date: 2013-05-30 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 9-12 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Saint Louis Veterans Affairs Medical Center, Saint Louis, Missouri, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aniline Compounds
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therapeutic use Calcinosis / complications, drug therapy*, prevention & control Calcium / agonists* Cardiovascular Diseases / prevention & control* Humans Naphthalenes / therapeutic use Receptors, Calcium-Sensing / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Aniline Compounds; 0/N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine; 0/Naphthalenes; 0/Receptors, Calcium-Sensing; 7440-70-2/Calcium; UAZ6V7728S/cinacalcet |
| Comments/Corrections | |
Comment On:
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Kidney Int. 2009 Jan;75(1):60-71
[PMID:
19092814
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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