Document Detail


A new role for RPTPsigma in spinal cord injury: signaling chondroitin sulfate proteoglycan inhibition.
MedLine Citation:
PMID:  20179269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been known for more than two decades that chondroitin sulfate proteoglycans (CSPGs) inhibit axonal growth and regeneration. In the adult nervous system, CSPGs are enriched in perineuronal nets, and their abundance is increased in reactive astrocytes following injury to brain or spinal cord. Degradation of chondroitin sulfate (CS) sugar moieties by the local infusion of the bacterial enzyme chondroitinase ABC (ChaseABC) enhances experience-dependent neuronal plasticity in the adult visual cortex and results in substantially improved behavioral outcomes after spinal cord injury (SCI). Although the positive effects of ChaseABC treatment on neuronal plasticity have been known for some time, the underlying mechanisms remained enigmatic. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory CSPGs. Similarly to ChaseABC treatment, functional ablation of Ptprs, the gene encoding RPTPsigma, promotes neurite outgrowth in the presence of CSPGs in vitro and enhances axonal growth into CSPG-rich scar tissue following SCI in vivo. The discovery of neuronal RPTPsigma as a receptor for inhibitory CSPGs not only provides important mechanistic clues about CSPG function, but also identifies a potential new target for enhancing axonal growth and plasticity after nervous system injury.
Authors:
Yuntao Duan; Roman J Giger
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Publication Detail:
Type:  Journal Article     Date:  2010-02-23
Journal Detail:
Title:  Science signaling     Volume:  3     ISSN:  1937-9145     ISO Abbreviation:  Sci Signal     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465400     Medline TA:  Sci Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  pe6     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology and Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Humans
Mice
Molecular Sequence Data
Nerve Regeneration / physiology*
Neuronal Plasticity / physiology*
Proteochondroitin Sulfates / antagonists & inhibitors*
Receptor-Like Protein Tyrosine Phosphatases, Class 2 / genetics,  metabolism*
Receptors, Cell Surface / metabolism*
Signal Transduction / physiology*
Spinal Cord Injuries / enzymology*
Chemical
Reg. No./Substance:
0/Proteochondroitin Sulfates; 0/Receptors, Cell Surface; 0/chondroitin sulfate proteoglycan receptor, human; EC 3.1.3.48/Receptor-Like Protein Tyrosine Phosphatases, Class 2

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