| A new rabbit model of myocardial infarction without endotracheal intubation. | |
| | |
MedLine Citation:
|
PMID: 14732358 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: When establishing a myocardial infarction model in rabbits, artificial ventilation under endotracheal intubation is required to prevent pulmonary collapse caused by pneumothorax. However, it is difficult to carry out endotracheal intubation due to the rabbit anatomy. We therefore attempted to develop a myocardial infarction model in rabbits without endotracheal intubation. MATERIALS AND METHODS: A facial oxygen mask with a flow rate of 200 mL/min was placed on anesthetized rabbits (n = 17). The sternum was carefully incised along the midline to avoid injury to the parietal pleura. The major branch of the left coronary artery was then ligated and the surgical wound was closed. To investigate the effects of the surgical procedure on physiological parameters, blood pressure and blood gas were measured during the same procedure using 10 other rabbits. RESULTS: During the surgery, PaO(2) and PaCO(2) were stable at approximately 230 and 50 mm Hg, respectively. In addition, the animals did not experience severe ventilatory impairment. Four weeks after the myocardial ischemia, the overall mortality rate was 29.4% (5/17). All of the surviving animals showed Q-waves on ECG and myocardial infarction upon histological examination. CONCLUSIONS: Our new method established a chronic rabbit model of myocardial infarction without the need for endotracheal intubation. |
| | |
Authors:
|
Masanori Fujita; Yuji Morimoto; Masayuki Ishihara; Masafumi Shimizu; Bonpei Takase; Tadaaki Maehara; Makoto Kikuchi |
Related Documents
:
|
12063298 - Melatonin as an effective protector against doxorubicin-induced cardiotoxicity. 8899548 - Naloxone blockade of myocardial ischemic preconditioning is stereoselective. 17579248 - Intrinsic defensive mechanisms in the heart: a potential novel approach to cardiac prot... 12003798 - Role of delta-opioid receptor agonists on infarct size reduction in swine. 8853138 - Immediate and long-term results of the splinting for acute closure trial. 22020348 - Usefulness of nt-pro-bnp and echocardiography in the diagnosis of subclinical clozapine... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of surgical research Volume: 116 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-20 Completed Date: 2004-02-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
|
Languages: eng Pagination: 124-8 Citation Subset: IM |
Affiliation:
|
Department of Medical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Saitama, Japan. BXB01424@nifty.ne.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carbon Dioxide / blood Disease Models, Animal* Electrocardiography Intubation, Intratracheal Male Myocardial Infarction* / blood, mortality, pathology Oxygen / blood Partial Pressure Rabbits* |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The lack of a systemic inflammatory response syndrome supports the safety of pancreatic electrolysis...
Next Document: The antitumor effects of interferon-alpha are maintained in mice challenged with a STAT1-deficient m...