Document Detail


A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trial.
MedLine Citation:
PMID:  22894624     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ω-3 fatty acids reduce triglyceride (TG) levels, but corresponding increases in low-density lipoprotein cholesterol (LDL-C) levels may compromise achievement of lipid goals in patients with elevated cardiovascular risk. AMR101 is an investigational agent containing ≥96% of pure icosapent ethyl (the ethyl ester of eicosapentaenoic acid). The Phase III Multi-Center, Placebo-Controlled, Randomized, Double-Blind, 12-Week Study with an Open-Label Extension (MARINE) investigated the efficacy and safety of AMR101 in 229 patients with very high TG levels (≥500 mg/dl). AMR101 4 g/day significantly reduced median placebo-adjusted TG levels from baseline by 33.1% (p < 0.0001), and AMR101 2 g/day reduced TG levels by 19.7% (p = 0.0051). Changes in LDL-C were minimal and nonsignificant. AMR101 may offer substantial TG lowering without increases in LDL-C levels.
Authors:
Terry A Jacobson
Related Documents :
3062744 - Strategies for in situ hybridization.
18280784 - Vibrational spectroscopic studies and ab initio calculations of 5-nitro-2-(p-fluorophen...
7956204 - Interactions of matrix proteins from mineralized tissues with octacalcium phosphate.
19625494 - Conformational analysis of nucleic acids revisited: curves+.
14519914 - Formulation study for lansoprazole fast-disintegrating tablet. iii. design of rapidly d...
15180384 - Effects of methoprene, its metabolites, and breakdown products on retinoid-activated pa...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  10     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-08-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  687-95     Citation Subset:  IM    
Affiliation:
Department of Medicine, Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA, USA. tjaco02@emory.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  General Entry to Asymmetric One-Pot [N+2+n] Cyclization for the Synthesis of 3- to 7-Membered Azacyc...
Next Document:  Insights from the RCPE UK Consensus Conference on approaching the comprehensive management of atrial...