| A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence. | |
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MedLine Citation:
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PMID: 19408306 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have discovered a new, ultrafast therapy for treating skin cancer that is extremely effective with a total electric field exposure time of only 180 microsec. The application of 300 high-voltage (40 kV/cm), ultrashort (300 nsec) electrical pulses to murine melanomas in vivo triggers both necrosis and apoptosis, resulting in complete tumor remission within an average of 47 days in the 17 animals treated. None of these melanomas recurred during a 4-month period after the initial melanoma had disappeared. These pulses generate small, long-lasting, rectifying nanopores in the plasma membrane of exposed cells, resulting in increased membrane permeability to small molecules and ions, as well as an increase in intracellular Ca(2+), DNA fragmentation, disruption of the tumor's blood supply and the initiation of apoptosis. Apoptosis was indicated by a 3-fold increase in Bad labeling and a 72% decrease in Bcl-2 labeling. In addition, microvessel density within the treated tumors fell by 93%. This new therapy utilizing nanosecond pulsed electric fields has the advantages of highly localized targeting of tumor cells and a total exposure time of only 180 microsec. These pulses penetrate into the interior of every tumor cell and initiate DNA fragmentation and apoptosis while at the same time reducing blood flow to the tumor. This new physical tumor therapy is drug free, highly localized, uses low energy, has no significant side effects and results in very little scarring. |
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Authors:
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Richard Nuccitelli; Xinhua Chen; Andrei G Pakhomov; Wallace H Baldwin; Saleh Sheikh; Jennifer L Pomicter; Wei Ren; Christopher Osgood; R James Swanson; Juergen F Kolb; Stephen J Beebe; Karl H Schoenbach |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 125 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-06-19 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 438-45 Citation Subset: IM |
Copyright Information:
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Copyright 2009 UICC. |
Affiliation:
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Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23510, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Electric Stimulation Therapy* Female Immunohistochemistry Melanoma, Experimental / blood supply, therapy* Mice Mice, Nude Patch-Clamp Techniques Recurrence Remission Induction Skin Neoplasms / blood supply, metabolism, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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R43 CA123924-01A2/CA/NCI NIH HHS; R44 CA117227-03/CA/NCI NIH HHS; R44 CA123924-03/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium |
| Comments/Corrections | |
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