| A new perspective on cardiotoxicity of 5-fluorouracil. A novel research tool 'cardiac ultrasonic integrated backscatter analysis' indicates transient, subclinical myocardial dysfunction due to high-dose leucovorin and infusional 5-fluorouracil regimen. | |
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MedLine Citation:
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PMID: 15272225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The pathophysiology of 5-fluorouracil (5-FU) cardiotoxicity is still controversial. The objective of this study was to assess the influence of high-dose leucovorin and infusional 5-FU regimen (HDLV5FU) on cardiac tissues. METHODS: We monitored 28 patients (median age 68 years) under HDLV5FU chemotherapy with complete blood counts, cardiac enzymes, C-reactive protein, coagulation tests, Holter electrocardiogram, and conventional echocardiography. Cardiac ultrasonic tissue characterization with integrated backscatter (IBS) analysis was performed in the 16 last enrolled patients. RESULTS: The magnitude of both anterior and posterior cardiac IBS values significantly decreased at the 48th hour of treatment compared to both 0th hour and day 15 (p < 0.003). Cardiac IBS values on the 15th day were not different from the 0th hour. Clinical cardiotoxicity was not observed and other monitored parameters did not change significantly in any patient (p > 0.5 for all). CONCLUSION: Cardiac IBS analysis suggests that 5-FU might cause reversible subclinical myocardial dysfunction. |
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Authors:
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Sabri Barutca; Ceyhun Ceyhan; Nezih Meydan; Banu Ozturk; Tarkan Tekten; Alper Onbasili; Gurhan Kadikoylu; Zahit Bolaman |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 50 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-07-23 Completed Date: 2005-01-11 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: Switzerland |
Other Details:
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Languages: eng Pagination: 113-8 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Adnan Menderes University Hospital, Aydin, Turkey. sbarutca@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antimetabolites, Antineoplastic / administration & dosage, adverse effects*, therapeutic use Colorectal Neoplasms / blood, drug therapy*, ultrasonography Drug Therapy, Combination Echocardiography / methods* Electrocardiography, Ambulatory Female Fluorouracil / administration & dosage, adverse effects*, therapeutic use Heart / drug effects*, physiopathology Humans Infusions, Intravenous Injections, Intravenous Leucovorin / administration & dosage, therapeutic use Male Middle Aged Myocardial Contraction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 51-21-8/Fluorouracil; 58-05-9/Leucovorin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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