Document Detail

A new percutaneous porcine coronary model of chronic total occlusion.
MedLine Citation:
PMID:  16145229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Chronic total occlusion (CTO) of coronary arteries represents a challenge for percutaneous treatment. Although ameroid constrictors have been used to create CTOs from extrinsic compression of coronary arteries, this model is not suitable for evaluation of novel angioplasty equipment. Thus, the objective of this study was to create a new percutaneous animal model of CTO. METHODS: To create an animal model of CTO, we implanted copper-plated stents in the left circumflex coronary arteries of 18 pigs, and assigned the pigs to early group (n = 6; sacrifice at approximately 1 week), intermediate group (n = 6; sacrifice at approximately 4 weeks), and late group (n = 6; sacrifice at approximately 8 weeks). RESULTS: Follow-up angiography prior to sacrifice revealed complete occlusion in 14 of 17 animals, with the subtotal occlusive lesions (mean 60% stenosis) only in the early group. Most of the pigs with total occlusions (12 of 14) showed bridging collateral flow greater than or equal to grade 2 (grade 2: 4; grade 3: 8). Histology revealed organizing thrombus in the early group with persistent inflammation, and organized thrombus with fibrosis and calcification in the intermediate and late groups. Interestingly, there were fibrotic components in the proximal and distal edges of the occlusions with softer, organizing thrombus in the middle of the CTO in the late group, suggesting that the major areas of difficulty are at the entrance and exit segments of the CTO with percutaneous recanalization. CONCLUSION: This study shows the feasibility and reproducibility of a new porcine coronary percutaneous CTO model. This model may be useful in improving our percutaneous treatment of CTO.
Woohyuk Song; Jaeung Lee; Hyunjoong Kim; Jinho Shin; Dongjoo Oh; Fermin Tio; S Chiu Wong; Mun K Hong
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of invasive cardiology     Volume:  17     ISSN:  1042-3931     ISO Abbreviation:  J Invasive Cardiol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-07     Completed Date:  2005-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8917477     Medline TA:  J Invasive Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-4     Citation Subset:  IM    
Department of Medicine, Weill Cornell Medical College, 525 East 68th Street, F439, New York, Nork 10021, USA.
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MeSH Terms
Blood Vessel Prosthesis Implantation / instrumentation*
Chronic Disease
Coronary Angiography
Coronary Disease / pathology,  radiography,  surgery*
Coronary Vessels / pathology,  surgery
Disease Models, Animal*
Feasibility Studies
Follow-Up Studies
Pilot Projects
Reproducibility of Results
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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