Document Detail


A new paradigm in cell therapy for diabetes: turning pancreatic α-cells into β-cells.
MedLine Citation:
PMID:  20803505     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Cell therapy means treating diseases with the body's own cells. One of the cell types most in demand for therapeutic purposes is the pancreatic β-cell. This is because diabetes is one of the major healthcare problems in the world. Diabetes can be treated by islet transplantation but the major limitation is the shortage of organ donors. To overcome the shortfall in donors, alternative sources of pancreatic β-cells must be found. Potential sources include embryonic or adult stem cells or, from existing β-cells. There is now a startling new addition to this list of therapies: the pancreatic α-cell. Thorel and colleagues recently showed that under circumstances of extreme pancreatic β-cell loss, α-cells may serve to replenish the insulin-producing compartment. This conversion of α-cells to β-cells represents an example of transdifferentiation. Understanding the molecular basis for transdifferentiation may help to enhance the generation of β-cells for the treatment of diabetes.
Authors:
Caroline B Sangan; David Tosh
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Publication Detail:
Type:  Journal Article     Date:  2010-08-27
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  32     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  881-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 WILEY Periodicals, Inc.
Affiliation:
Centre for Regenerative Medicine, Department of Biology & Biochemistry, University of Bath, Claverton Down, Bath BA27AY, UK.
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