Document Detail

A new oxygenation index for reflecting intrapulmonary shunting in patients undergoing open-heart surgery.
MedLine Citation:
PMID:  14769743     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To assess the reliability of new and traditional oxygenation measurements in reflecting intrapulmonary shunt.
DESIGN: Prospective study.
SETTING: Cardiac surgery unit at a university hospital.
PATIENTS: Fifty-five patients undergoing coronary artery bypass grafting.
MEASUREMENTS AND RESULTS: Simultaneous blood samples were collected from an indwelling arterial line and a catheter for determination of blood gases. Standard accepted formulas were utilized to measure a new oxygenation index: PaO(2)/fraction of inspired oxygen (FIO(2)) x mean airway pressure (Paw). The standard formulas used were the oxygenation ratio (PaO(2)/FIO(2)), PaO(2)/alveolar partial oxygen pressure (PAO(2)), alveolar-arterial oxygen tension gradient (P[A-a]O(2)), and intrapulmonary shunt (venous admixture [Qsp/Qt]). There were significant negative (p < 0.05) correlations between the PaO(2)/(FIO(2) x Paw) and Qsp/Qt (r = - 0.85), between the PaO(2)/FIO(2) and Qsp/Qt (r = - 0.74), and between the PaO(2)/PAO(2) and Qsp/Qt (r = - 0.71). There was a significant positive (p < 0.05) correlation between the P(A-a)O(2) gradient and Qsp/Qt (r = 0.66). However, the correlation was strongest between the PaO(2)/(FIO(2) x Paw) and Qsp/Qt.
CONCLUSION: In this group of patients, PaO(2)/(FIO(2) x Paw) might be more reliable than other oxygenation measurements in reflecting intrapulmonary shunt.
Mohamad F El-Khatib; Ghassan W Jamaleddine
Related Documents :
7330493 - Adaptation of hemoglobin function to subterranean life in the mole, talpa europaea.
22509723 - Overall stability for the ibuprofen racemate: experimental and topological results lead...
7463353 - Effects of sotalol and vagal stimulation on ischemic myocardial blood flow distribution...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  125     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-10     Completed Date:  2004-03-11     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Physiological
Blood Gas Analysis
Carbon Dioxide / blood*
Coronary Artery Bypass / methods*
Coronary Disease / diagnosis,  surgery*
Follow-Up Studies
Hospitals, University
Middle Aged
Monitoring, Intraoperative
Positive-Pressure Respiration*
Postoperative Care / methods
Prospective Studies
Pulmonary Circulation / physiology*
Pulmonary Gas Exchange / physiology*
Respiratory Function Tests
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
142M471B3J/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Transpyloric feeding tube placement in critically ill patients using electromyogram and erythromycin...
Next Document:  Prevalence and outcomes of caregiving after prolonged (> or =48 hours) mechanical ventilation in the...