Document Detail


A new oxygenation index for reflecting intrapulmonary shunting in patients undergoing open-heart surgery.
MedLine Citation:
PMID:  14769743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STUDY OBJECTIVES: To assess the reliability of new and traditional oxygenation measurements in reflecting intrapulmonary shunt.
DESIGN: Prospective study.
SETTING: Cardiac surgery unit at a university hospital.
PATIENTS: Fifty-five patients undergoing coronary artery bypass grafting.
MEASUREMENTS AND RESULTS: Simultaneous blood samples were collected from an indwelling arterial line and a catheter for determination of blood gases. Standard accepted formulas were utilized to measure a new oxygenation index: PaO(2)/fraction of inspired oxygen (FIO(2)) x mean airway pressure (Paw). The standard formulas used were the oxygenation ratio (PaO(2)/FIO(2)), PaO(2)/alveolar partial oxygen pressure (PAO(2)), alveolar-arterial oxygen tension gradient (P[A-a]O(2)), and intrapulmonary shunt (venous admixture [Qsp/Qt]). There were significant negative (p < 0.05) correlations between the PaO(2)/(FIO(2) x Paw) and Qsp/Qt (r = - 0.85), between the PaO(2)/FIO(2) and Qsp/Qt (r = - 0.74), and between the PaO(2)/PAO(2) and Qsp/Qt (r = - 0.71). There was a significant positive (p < 0.05) correlation between the P(A-a)O(2) gradient and Qsp/Qt (r = 0.66). However, the correlation was strongest between the PaO(2)/(FIO(2) x Paw) and Qsp/Qt.
CONCLUSION: In this group of patients, PaO(2)/(FIO(2) x Paw) might be more reliable than other oxygenation measurements in reflecting intrapulmonary shunt.
Authors:
Mohamad F El-Khatib; Ghassan W Jamaleddine
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  125     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-10     Completed Date:  2004-03-11     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Aged
Blood Gas Analysis
Carbon Dioxide / blood*
Coronary Artery Bypass / methods*
Coronary Disease / diagnosis,  surgery*
Female
Follow-Up Studies
Hospitals, University
Humans
Male
Middle Aged
Monitoring, Intraoperative
Oximetry
Positive-Pressure Respiration*
Postoperative Care / methods
Probability
Prospective Studies
Pulmonary Circulation / physiology*
Pulmonary Gas Exchange / physiology*
Respiratory Function Tests
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Chemical
Reg. No./Substance:
142M471B3J/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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