| A new oral otoprotective agent. Part 1: Electrophysiology data from protection against noise-induced hearing loss. | |
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MedLine Citation:
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PMID: 22207104 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Data from animal studies show that antioxidants can compensate against noise-induced stress and sensory hair cell death. The aim of this study was to evaluate the otoprotection efficacy of various versions of orally administered Acuval 400® against noise damage in a rat animal model.<br /> Material/Methods: Fifty-five Sprague Dawley rats were divided into 4 groups: A) noise-exposed animals; B) animals exposed to noise and treated with the Acuval; C) animals exposed to noise and treated with a combination of Coenzyme Q10 and Acuval; D) animals treated only with Acuval and Coenzyme Q10 and with no exposure to noise. All solutions were administered orally 5 times: 24 and 2 hrs prior to noise exposure, and then daily for 3 days. The auditory function was assessed by measuring auditory brainstem responses (ABR) in the range from 2 to 32 kHz at times =1, 7, 14 and 21 days after noise exposure.<br /> Results: At low frequencies (click and 4 kHz) animals from both A and B groups showed significant threshold shifts in the majority of the tested frequencies and tested times. For the same frequencies, animals from group C presented threshold levels similar to those from group D. At frequencies ≥8 kHz the protective performance of the 2 Acuval groups is more clearly distinguished from the noise group A. At 32 kHz the 2 Acuval groups perform equally well in terms of otoprotection. Animals in Group D did not show any significant differences in the hearing threshold during the experiment.<br /> Conclusions: The data of this study suggest that a solution containing Coenzyme Q10 and Acuval 400®, administered orally, protects from noise-induced hearing loss.<br /> |
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Authors:
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Vincenza Cascella; Pietro Giordano; Stavros Hatzopoulos; Joseph Petruccelli; Silvano Prosser; Edi Simoni; Laura Astolfi; Anna Rita Fetoni; Henryk Skarżyński; Alessandro Martini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 18 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: BR1-8 Citation Subset: IM |
Affiliation:
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Center of Bioacoustics, University of Ferrara, Ferrara, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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