Document Detail


A new motor test sensitive to aging and dopaminergic function.
MedLine Citation:
PMID:  1798345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neurodegenerative disorders which involve motor impairment is characteristic of old age. Although there are a few tests which attempt to assess motor incapacities, many have utilized scales which have either a great deal of subjective evaluations or are subject to learning-performance complexities. This study describes a method able to measure motor impairment of aging rats which is subject to dopaminergic influences and has negligible practice effects. The test is designed so that rats have to traverse 2 meter beams of 15 degrees inclination whose widths 3, 6, 12, 18 and 24 mm are changed on each test session using a table of random numbers. The time ceiling allowed for traversing the 2 m beams was established at 120 sec. 3-month-old rats (n = 20) and aged rats (n = 20) with a mean age of 26.5 +/- 3.8 months ranging from 23 to 34 months were utilized in this study. All young rats traversed the beams, independently of beam width, while virtually none of the old rats traversed the 3 and 6 mm beams. However, as the beam width increased more and more aged rats ascended the beam. Nevertheless, there were always a few old rats who were unable to cross even on the widest beam. When young rats were fitted with a lead belt which increased their body weight by approximately 40%, they still traversed all beam widths. On the other hand, haloperidol (0.1 and 0.2 mg/kg) severely impaired the performance of young rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
R Drucker-Colín; F García-Hernández
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  39     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-04-16     Completed Date:  1992-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  153-61     Citation Subset:  IM    
Affiliation:
Depto. de Neurociencias, Universidad Nacional Autónoma de México, D.F.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Body Weight
Dextroamphetamine / pharmacology
Dopamine / physiology*
Haloperidol / pharmacology
Levodopa / pharmacology
Male
Motor Activity* / drug effects,  physiology
Neuropsychological Tests*
Rats
Rats, Inbred Strains / physiology*
Chemical
Reg. No./Substance:
0/Levodopa; 51-64-9/Dextroamphetamine; 52-86-8/Haloperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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