| A new monoterpene acid from Marrubium vulgare with potential antihepatotoxic activity. | |
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MedLine Citation:
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PMID: 20628963 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The whole plant of Marrubium vulgare L. afforded a new terpenoid, characterised as p-menthane-5,6-dihydroxy-3-carboxylic acid (1), which has been designated as marrubic acid. Its structure has been elucidated on the basis of spectral and chemical analyses. The compound (1) also exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 40.16%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 35.06%, and alkaline phosphatase (ALP) by 30.51%. On the other hand, total protein (TP) levels were increased by 34.07%, as compared to the standard drug silymarin, which decreased SGOT by 53.04%, SGPT by 55.96%, ALP by 35.87% and increased TP levels by 59.59%. These biochemical observations were also supplemented by histopathological examinations of liver sections. |
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Authors:
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Bahar Ahmed; Mubashir H Masoodi; Anwarul H Siddique; Shamshir Khan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Natural product research Volume: 24 ISSN: 1478-6427 ISO Abbreviation: Nat. Prod. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 1671-80 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India. drbahmed@rediffmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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