Document Detail


A new modified gamma-%CDT method improves the detection of problem drinking: studies in alcoholics with or without liver disease.
MedLine Citation:
PMID:  14637264     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The detection of excessive alcohol consumption by laboratory methods continues to lack sensitivity and specificity. Recent studies have suggested that diagnostic improvement may be achieved by combining carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GT) measurements into a marker defined as gamma-CDT. METHODS: We developed a new approach for determining gamma-CDT by using the data obtained from the Axis %CDT turbidimetric assays. Marker results were compared in the assessment of 65 alcoholics, who were either with (n=34) or without (n=31) liver disease, as analysed by clinical, laboratory, and morphological criteria. Reference individuals were 45 healthy volunteers who were either social drinkers or abstainers. RESULTS: Gamma-GT and CDT results derived from both CDTect and %CDT measurements were used to calculate marker ratios as follows 0.8 x ln(GT)+1.3 x ln(CDT). With the established cut-off of 4.0 for the gamma-%CDT, the sensitivity of this method was 94% for men and 82% for women, as compared to 61% and 46% for %CDT and 70% and 73% for GT. The gamma-%CDT method was less dependent on liver status than the various other markers and showed the highest correlation with self-reported alcohol consumption (r=0.7254). CONCLUSIONS: The data indicates that the new gamma-%CDT method yields improved diagnostic accuracy for the detection of excessive ethanol consumption.
Authors:
Petra Anttila; Kimmo Järvi; Jaana Latvala; Joan E Blake; Onni Niemelä
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  338     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, University of Tampere, Tampere, Finland.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking / metabolism
Alcoholism / complications*,  diagnosis*,  metabolism
Female
Humans
Liver Diseases / complications*,  metabolism*
Male
Middle Aged
Sensitivity and Specificity
Sex Characteristics
Transferrin / analogs & derivatives*,  analysis*
Chemical
Reg. No./Substance:
0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin

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