| A new modified gamma-%CDT method improves the detection of problem drinking: studies in alcoholics with or without liver disease. | |
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MedLine Citation:
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PMID: 14637264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The detection of excessive alcohol consumption by laboratory methods continues to lack sensitivity and specificity. Recent studies have suggested that diagnostic improvement may be achieved by combining carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GT) measurements into a marker defined as gamma-CDT. METHODS: We developed a new approach for determining gamma-CDT by using the data obtained from the Axis %CDT turbidimetric assays. Marker results were compared in the assessment of 65 alcoholics, who were either with (n=34) or without (n=31) liver disease, as analysed by clinical, laboratory, and morphological criteria. Reference individuals were 45 healthy volunteers who were either social drinkers or abstainers. RESULTS: Gamma-GT and CDT results derived from both CDTect and %CDT measurements were used to calculate marker ratios as follows 0.8 x ln(GT)+1.3 x ln(CDT). With the established cut-off of 4.0 for the gamma-%CDT, the sensitivity of this method was 94% for men and 82% for women, as compared to 61% and 46% for %CDT and 70% and 73% for GT. The gamma-%CDT method was less dependent on liver status than the various other markers and showed the highest correlation with self-reported alcohol consumption (r=0.7254). CONCLUSIONS: The data indicates that the new gamma-%CDT method yields improved diagnostic accuracy for the detection of excessive ethanol consumption. |
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Authors:
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Petra Anttila; Kimmo Järvi; Jaana Latvala; Joan E Blake; Onni Niemelä |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 338 ISSN: 0009-8981 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2004-07-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, University of Tampere, Tampere, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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metabolism Alcoholism / complications*, diagnosis*, metabolism Female Humans Liver Diseases / complications*, metabolism* Male Middle Aged Sensitivity and Specificity Sex Characteristics Transferrin / analogs & derivatives*, analysis* |
| Chemical | |
Reg. No./Substance:
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0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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