Document Detail


A new model of concussive brain injury in the cat produced by extradural fluid volume loading: I. Biomechanical properties.
MedLine Citation:
PMID:  3454675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study presents a new device for producing experimental, concussive head injury together with a detailed description of biomechanical features of fluid percussion brain injury in the cat. Anaesthetized cats were subjected to multiple (N = 3) or single injuries (N = 87). The variables studied in repeated injury experiments included the volume of fluid injected intracranially, rate of fluid flow, and the associated pressure transients recorded extracranially in the injury device and intracranially at supratentorial and infratentorial sites. Peak fluid flow increased with increasing volumes of fluid loaded intracranially. Extracranial pressure peaks and durations increased when volume loading was increased. Extracranial and intracranial pressure transients were similar at all recording sites. The form of pressure transients recorded in single injury experiments was similar to that recorded in multiple injury experiments. In single injury experiments, the extracranial pressure peaks and durations also increased with increased intracranial fluid volume loading. The slopes describing the relationships between intracranial volume loading and extracranial pressure transients were significantly different in single and multiple injury experiments. Details of the design and use of the head injury device are also discussed.
Authors:
D Stalhammar; B J Galinat; A M Allen; D P Becker; H H Stonnington; R L Hayes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain injury : [BI]     Volume:  1     ISSN:  0269-9052     ISO Abbreviation:  Brain Inj     Publication Date:    1987 Jul-Sep
Date Detail:
Created Date:  1988-10-06     Completed Date:  1988-10-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-91     Citation Subset:  IM    
Affiliation:
Richard Roland Reynolds Neurosurgical Research Laboratories, Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0001.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Brain / physiopathology*
Brain Concussion / etiology*,  physiopathology
Cats
Female
Fluid Therapy / instrumentation
Intracranial Pressure*
Male
Grant Support
ID/Acronym/Agency:
NS 12587/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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