Document Detail

A new method of total parenteral nutrition for surgical neonates: it is possible that cyclic TPN prevents intrahepatic cholestasis.
MedLine Citation:
PMID:  2128784     Owner:  NLM     Status:  MEDLINE    
Cholestasis associated with total parenteral nutrition (TPN) has been reported to be an incidence of 15% to 50% in surgical neonates. This study was designed to prevent the liver dysfunction, especially intrahepatic cholestasis, caused by TPN for surgical neonates. In the last three years, 10 surgical neonates ranged from 1868g to 3500g of birth weight have been treated by cyclic TPN that infuses solutions of TPN and Non-TPN alternately every four hours, because cyclic TPN may reduce an overloading for the liver by the compulsive and continuous TPN. Consequently, no hyperbilirubinemia and abnormal values of the serum transaminases were revealed in these neonates, and good results of nutritional supports were obtained by cyclic TPN. These results suggest that cyclic TPN is useful and safe in nutritional support for neonates, and cyclic TPN is much better than continuous TPN in order to prevent the liver dysfunction.
H Takehara; M Hino; K Kameoka; N Komi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tokushima journal of experimental medicine     Volume:  37     ISSN:  0040-8875     ISO Abbreviation:  Tokushima J. Exp. Med.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-06-26     Completed Date:  1991-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417356     Medline TA:  Tokushima J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  IM    
1st Department of Surgery, School of Medicine, University of Tokushima, Japan.
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MeSH Terms
Alanine Transaminase / analysis
Aspartate Aminotransferases / analysis
Bilirubin / analysis
Blood Glucose / analysis
Cholestasis / prevention & control*
Infant, Newborn
Infusions, Parenteral
Parenteral Nutrition, Total / methods*
Surgical Procedures, Operative / methods*
Reg. No./Substance:
0/Blood Glucose; 635-65-4/Bilirubin; EC Aminotransferases; EC Transaminase

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