Document Detail


A new method for measurement of blood pressure, heart rate, and activity in the mouse by radiotelemetry.
MedLine Citation:
PMID:  10797109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple and reliable means for accurate, chronic measurement of pulsatile blood pressure (BP) from conscious, freely moving laboratory mice was developed and validated. The newly developed device consists of a small (1.9 ml, 3.4 g), fully implantable radiotelemetry transmitter. Initial frequency response tests showed an adequate dynamic response; the average -3-dB point found in five transmitters was 145 +/- 14 (SD) Hz. BP, heart rate, and locomotor activity were recorded from 16 chronically (30-150 days) implanted mice. Mean arterial and pulse pressure, checked at regular intervals, ranged from 90-140 mmHg and from 30-50 mmHg, respectively, throughout the study. Transmitter BP measurements were validated against a Millar 1.4-Fr. transducer-tipped catheter. The mean error of the transmitters for diastolic pressures was +1.1 +/- 6.9 mmHg (n = 7). The error for systolic pressures was, on average, 2.7 +/- 3.9 mmHg larger. This new device accurately monitors BP, heart rate, and locomotor activity in conscious, untethered, freely moving mice living in their home cages for periods of at least 150 days.
Authors:
P A Mills; D A Huetteman; B P Brockway; L M Zwiers; A J Gelsema; R S Schwartz; K Kramer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-23     Completed Date:  2000-06-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1537-44     Citation Subset:  IM    
Affiliation:
Data Sciences International, St. Paul, Minnesota 55126, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials
Blood Pressure*
Equipment Design
Heart Rate*
Mice
Monitoring, Physiologic
Motor Activity / physiology
Telemetry* / instrumentation
Grant Support
ID/Acronym/Agency:
1R43HL55823-01/HL/NHLBI NIH HHS; 2R44HL55823-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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