Document Detail

A new method for evaluation of portasystemic shunting. The rectal octanoate tolerance test.
MedLine Citation:
PMID:  5212384     Owner:  NLM     Status:  MEDLINE    
Hepatic clearance of a small dose of a medium chain fatty acid was used to estimate portasystemic shunting in patients with cirrhosis. Sodium octanoate dissolved in isotonic saline was administered by rectum (11.4 mg per kg of lean body mass) in three groups of 10 patients with cirrhosis and in 10 noncirrhotic controls. Two groups of patients were classified as mild and severe cirrhotics on the basis of a clinical evaluation. The third group of cirrhotic patients had a surgical portacaval shunt. Serum octanoate levels were measured in each subject for a 1-hr period following the administration of sodium octanoate by rectum. A highly significant difference (P less than 0.001) was demonstrated between all four groups of subjects with highest levels occurring in the shunted cirrhotics and the lowest levels in the control group. Serum levels obtained in 2 patients before and after a portacaval shunt increased by a factor of 2 following the operation. Two patients with proven occlusion of a surgical shunt fell well within the range of the nonoperated cirrhotic patients. The results suggest that the rectal octanoate tolerance test can probably be used for evaluation of collateral circulation in cirrhotic patients and for testing the patency of surgical shunts.
W G Linscheer; D O Castell; R R Platt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  57     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1969 Oct 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-23     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Rectal
Ammonia / diagnostic use
Caprylates / diagnostic use*
Collateral Circulation
Liver Circulation
Liver Cirrhosis / surgery
Middle Aged
Octanoic Acids / administration & dosage,  diagnostic use*
Portasystemic Shunt, Surgical*
Grant Support
Reg. No./Substance:
0/Caprylates; 0/Octanoic Acids; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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