| A new method for distinguishing between enantiomers and racemates and assignment of enantiomeric purity by means of solid-state NMR. Examples from oxazaphosphorinanes. | |
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MedLine Citation:
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PMID: 12489534 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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It is shown that enantiomers and racemates that have identical isotropic NMR chemical shift as well as anisotropic chemical-shift tensor parameters can be easily distinguished by means of the ODESSA (One Dimensional Exchange Spectroscopy by Sideband Alternation) technique. The method is based on the fact that the molecular symmetries and packing of enantiomers and racemates are usually significantly different. The power of the proposed approach is demonstrated by employing as model compounds P-chiral oxazaphosphorine derivatives, which are widely used in clinical oncology. Correlation of the amplitude of the ODESSA decay (AOD) with enantiomeric excess is also presented. |
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Authors:
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Marek J Potrzebowski; Elzbieta Tadeusiak; Konrad Misiura; Włodzimierz Ciesielski; Grzegorz Bujacz; Piotr Tekely |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: 8 ISSN: 0947-6539 ISO Abbreviation: Chemistry Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-12-18 Completed Date: 2003-07-25 Revised Date: 2009-08-04 |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: Germany |
Other Details:
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Languages: eng Pagination: 5007-11 Citation Subset: - |
Affiliation:
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Department of Structural Studies, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza, Łódź, Poland. marekpot@bilbo.cbmm.lodz.pl |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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