Document Detail

A new method of bone tissue measurement based upon light scattering.
MedLine Citation:
PMID:  9041059     Owner:  NLM     Status:  MEDLINE    
In recent years, time-resolved spectroscopy systems using near infrared pulsed laser have been applied to develop optical computed tomography. We applied this technique to measure the optical properties of osseous tissues. First, we gradually demineralized 10 mm blocks of bovine trabecular bone with EDTA, maintaining the absorption characteristics and structure but varying the hydroxyapatite content, thus creating specimens differing only in light scattering properties. We used computer densitograms to assess light penetration, and analyzed the correlation with bone mineral density (BMD) as with dual-energy X-ray absorptiometry scans. The light penetration increased with decreasing BMD. Second, using the above-mentioned pulsed laser time-resolved spectroscopy system, we investigated the correlation between the BMD and the time response waveforms of 10-mm blocks of bovine cortical bone, trabecular bone, and surrounding tissue as well as human trabecular bone. The human lumbar vertebral bone also displayed an inverse correlation between BMD and maximum light penetration and a positive correlation between BMD and peak time delay. This is the first demonstration of a correlation between BMD and light scattering properties showing that BMD can indeed be measured with light. Our results show the possibility of obtaining information on internal bone structure and composition in vivo through assessment of the waveforms obtained by a time-resolution system in the near infrared region.
A Takeuchi; R Araki; S G Proskurin; Y Takahashi; Y Yamada; J Ishii; S Katayama; A Itabashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research     Volume:  12     ISSN:  0884-0431     ISO Abbreviation:  J. Bone Miner. Res.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-22     Completed Date:  1997-05-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610640     Medline TA:  J Bone Miner Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Department of Internal Medicine IV, Saitama Medical School, Japan.
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MeSH Terms
Bone Density / physiology*
Lasers / diagnostic use*
Nephelometry and Turbidimetry / instrumentation*,  methods*
Scattering, Radiation
Spectroscopy, Near-Infrared / methods

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