Document Detail

A new method for the assessment of tissue hemoglobin oxygenation in patients with chronic venous insufficiency.
MedLine Citation:
PMID:  8992231     Owner:  NLM     Status:  MEDLINE    
Venous incompetence often leads to ulceration of the skin of the lower limb due to a disturbance of skin microcirculation. We investigated 10 healthy subjects and 18 patients with chronic venous insufficiency by means of a fast scanning reflection photometer and determined noninvasively the hemoglobin oxygen saturation (S(HB)) and the relative concentration of hemoglobin (C(HB)) in the skin of the forefoot and at the calf, 10 cm proximal of the inner malleolus during positional changes. In supine position no significant differences were found. During sitting and standing S(HB) dropped and was significantly lower in patients at both locations (calf, standing, patients 22.2 +/- 10.6% vs controls 48.2 +/- 13.5%, P < 0.001). C(HB) increased in patients during standing from 0.71 to 2.13 +/- 0.33 aU (in controls from 0.69 to 1.49 +/- 0.28 aU, P < 0.001). Activation of the muscle pump decreased C(HB) and increased S(HB) in patients and in controls. After the movements were stopped, S(HB) decreased again and fell to the initial low values eight times faster in patients (7.4 +/- 5.3 vs 57.5 +/- 19.6 sec, P < 0.001). C(HB) increased four times faster in patients (7.2 +/- 6.1 vs 29.9 +/- 13.6 sec). In sitting and standing positions hemoglobin oxygenation in the skin of the lower limb was markedly reduced in patients, but normal perfusion conditions were restored in supine position, indicating reversibility of the changes. Reflection oxymetry seems a valuable tool for the assessment of chronic venous insufficiency. The substantially reduced oxygenation of dermal hemoglobin in standing patients may contribute to the development of venous ulcers.
J Thum; L Caspary; A Creutzig; K Alexander
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Microvascular research     Volume:  51     ISSN:  0026-2862     ISO Abbreviation:  Microvasc. Res.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-01-13     Completed Date:  1997-01-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-26     Citation Subset:  IM    
Department of Angiology, Medical School of Hannover, Hannover, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chronic Disease
Foot / blood supply
Hemoglobinometry / methods*
Leg / blood supply
Leg Ulcer / prevention & control
Middle Aged
Oxyhemoglobins / analysis*
Skin / blood supply*
Spectrophotometry / methods*
Venous Insufficiency / blood*,  pathology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fibroblasts are in a position to provide directional information to migrating neutrophils during pne...
Next Document:  Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based net...