| A new lignan glycoside from Juniperus rigida. | |
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MedLine Citation:
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PMID: 22210029 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A new lignan glycoside, named juniperigiside (1) was isolated from the CHCl(3) soluble fraction of the MeOH extract of stems and leaves of Juniperus rigida S.et Z. Compound 1 was identified by 1D- and 2D-NMR spectroscopy as well as CD analysis as (2R,3S)-2,3-dihydro-7-methoxy-2-(4'-hydroxy-3'-methoxyphenyl)-3-hydroxymethyl-5-benzofuranpropanol 4'-O-(3-O-methyl)-α-L-rhamnopyranoside. Five known lignans, icariside E4 (2), desoxypodophyllotoxin (3), savinin (4), thujastandin (5), and (-)-nortrachelogenin (6) in addition to five known labdane diterpenes including trans-communic acid (7), 13-epi-torulosal (8), 13-epi-cupressic acid (9), imbricatoric acid (10), and isocupressic acid (11) were also isolated and their structures were characterized by comparing their spectroscopic data with those in the literature. All compounds were isolated for the first time from this plant, and 5 and 6 were first reported from the genus Juniperus. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay. Compounds 3, 4, 7, and 8 showed considerable cytotoxicity against four human cancer cell lines in vitro. |
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Authors:
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Kyeong Wan Woo; Sang Un Choi; Jong Cheol Park; Kang Ro Lee |
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Publication Detail:
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Type: Journal Article Date: 2011-12-31 |
Journal Detail:
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Title: Archives of pharmacal research Volume: 34 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 2043-9 Citation Subset: IM |
Affiliation:
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Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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