Document Detail


A new in vitro cell line established from human oat cell carcinoma of the lung.
MedLine Citation:
PMID:  195719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new tissue culture line, OAT-1975, has been established from explant cultures of human oat cell carcinoma of the lung, characterized and maintained for more than 1 year. The cells grew in a monolayered sheet with 24 hr of population-doubling time and are capable of clonal growth with about 60% plating efficiency. The cells still retain unique morphological and structural characteristics of oat cell carcinoma and showed "tumor takes" when transplanted into nude mice and conditioned young Syrian Golden hamsters. The chromosome constitution of the cells is hypertriploid with a modal peak at 74. The permanent growth integrity of the present cell line made it possible to utilize it for cell biological studies. Cell inactivation experiments indicated that the cells are sensitive to X-rays and Mitomycin C when compared to the responses of HeLa S3 cells.
Authors:
H Ohara; T Okamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  37     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-09-29     Completed Date:  1977-09-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3088-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Small Cell / genetics,  pathology*,  secretion,  therapy
Cell Division
Cell Line*
Chromosome Aberrations
Cricetinae
Humans
Lung Neoplasms / genetics,  pathology*,  secretion,  therapy
Mice
Mice, Nude
Mitomycins / pharmacology
Neoplasm Transplantation
Neoplasms, Experimental / genetics,  pathology,  secretion,  therapy
Neurosecretion
Transplantation, Heterologous
Chemical
Reg. No./Substance:
0/Mitomycins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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