Document Detail

A new highly effective short-term therapy schedule for Helicobacter pylori eradication.
MedLine Citation:
PMID:  10848654     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although triple therapy regimens suggested in the Current European guidelines give fairly good results, several studies have reported an unsatisfactory Helicobacter pylori eradication rate (< 80%). AIM: To evaluate the efficacy of a new short-term treatment sequence on H. pylori eradication. METHODS: A total of 52 patients with H. pylori infection and either non-ulcer dyspepsia (34 patients) or peptic ulcer (18 patients) were enrolled to receive a 10-day therapy: omeprazole 20 mg b.d. plus amoxycillin 1 g b.d. for the first 5 days, followed by omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for the remaining 5 days. H. pylori infection at entry was assessed by rapid urease test and histology on biopsies from the antrum and the corpus. Bacterial eradication was assessed by endoscopy (peptic ulcer patients) or 13C urea breath test (non-ulcer dyspepsia patients) 4-6 weeks after therapy had ended. RESULTS: All patients completed the study. H. pylori eradication was achieved in all but one patient, with an eradication rate of 98% (95% CI: 94.3-100) with intention-to-treat analysis. Patient compliance was good (consumption of prescribed drugs > 95%) for all but one patient, who took the triple therapy regimen for 4 days instead of 5 days. No major side-effects were reported but three (6%) patients complained of mild side-effects. CONCLUSIONS: The use of this 'five plus five' therapy schedule as an initial treatment for H. pylori deserves further investigation.
A Zullo; V Rinaldi; S Winn; P Meddi; R Lionetti; C Hassan; C Ripani; G Tomaselli; A F Attili
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  14     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-01     Completed Date:  2000-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  715-8     Citation Subset:  IM    
Department of Clinical Medicine, Gastroenteology II, 'La Sapienza' University, Rome, Italy.
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MeSH Terms
Administration, Oral
Amoxicillin / administration & dosage,  therapeutic use
Anti-Bacterial Agents / administration & dosage*,  therapeutic use
Anti-Ulcer Agents / administration & dosage*,  therapeutic use
Antitrichomonal Agents / administration & dosage*,  therapeutic use
Clarithromycin / administration & dosage,  therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Helicobacter Infections / complications,  drug therapy*
Helicobacter pylori / pathogenicity*
Middle Aged
Omeprazole / administration & dosage,  therapeutic use
Patient Compliance
Penicillins / administration & dosage,  therapeutic use
Stomach Ulcer / etiology,  microbiology
Tinidazole / administration & dosage,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Antitrichomonal Agents; 0/Penicillins; 19387-91-8/Tinidazole; 26787-78-0/Amoxicillin; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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