| A new highly effective short-term therapy schedule for Helicobacter pylori eradication. | |
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MedLine Citation:
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PMID: 10848654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although triple therapy regimens suggested in the Current European guidelines give fairly good results, several studies have reported an unsatisfactory Helicobacter pylori eradication rate (< 80%). AIM: To evaluate the efficacy of a new short-term treatment sequence on H. pylori eradication. METHODS: A total of 52 patients with H. pylori infection and either non-ulcer dyspepsia (34 patients) or peptic ulcer (18 patients) were enrolled to receive a 10-day therapy: omeprazole 20 mg b.d. plus amoxycillin 1 g b.d. for the first 5 days, followed by omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and tinidazole 500 mg b.d. for the remaining 5 days. H. pylori infection at entry was assessed by rapid urease test and histology on biopsies from the antrum and the corpus. Bacterial eradication was assessed by endoscopy (peptic ulcer patients) or 13C urea breath test (non-ulcer dyspepsia patients) 4-6 weeks after therapy had ended. RESULTS: All patients completed the study. H. pylori eradication was achieved in all but one patient, with an eradication rate of 98% (95% CI: 94.3-100) with intention-to-treat analysis. Patient compliance was good (consumption of prescribed drugs > 95%) for all but one patient, who took the triple therapy regimen for 4 days instead of 5 days. No major side-effects were reported but three (6%) patients complained of mild side-effects. CONCLUSIONS: The use of this 'five plus five' therapy schedule as an initial treatment for H. pylori deserves further investigation. |
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Authors:
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A Zullo; V Rinaldi; S Winn; P Meddi; R Lionetti; C Hassan; C Ripani; G Tomaselli; A F Attili |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 14 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-08-01 Completed Date: 2000-08-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 715-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, Gastroenteology II, 'La Sapienza' University, Rome, Italy. s.morini@flashnet.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Amoxicillin / administration & dosage, therapeutic use Anti-Bacterial Agents / administration & dosage*, therapeutic use Anti-Ulcer Agents / administration & dosage*, therapeutic use Antitrichomonal Agents / administration & dosage*, therapeutic use Clarithromycin / administration & dosage, therapeutic use Drug Administration Schedule Drug Therapy, Combination Female Helicobacter Infections / complications, drug therapy* Helicobacter pylori / pathogenicity* Humans Male Middle Aged Omeprazole / administration & dosage, therapeutic use Patient Compliance Penicillins / administration & dosage, therapeutic use Stomach Ulcer / etiology, microbiology Tinidazole / administration & dosage, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Antitrichomonal Agents; 0/Penicillins; 19387-91-8/Tinidazole; 26787-78-0/Amoxicillin; 73590-58-6/Omeprazole; 81103-11-9/Clarithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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