Document Detail


A new high-resolution computed tomography (CT) segmentation method for trabecular bone architectural analysis.
MedLine Citation:
PMID:  19280676     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the last decade, high-resolution computed tomography (CT) and microcomputed tomography (micro-CT) have been increasingly used in anthropological studies and as a complement to traditional histological techniques. This is due in large part to the ability of CT techniques to nondestructively extract three-dimensional representations of bone structures. Despite prior studies employing CT techniques, no completely reliable method of bone segmentation has been established. Accurate preprocessing of digital data is crucial for measurement accuracy, especially when subtle structures such as trabecular bone are investigated. The research presented here is a new, reproducible, accurate, and fully automated computerized segmentation method for high-resolution CT datasets of fossil and recent cancellous bone: the Ray Casting Algorithm (RCA). We compare this technique with commonly used methods of image thresholding (i.e., the half-maximum height protocol and the automatic, adaptive iterative thresholding procedure). While the quality of the input images is crucial for conventional image segmentation, the RCA method is robust regarding the signal to noise ratio, beam hardening, ring artifacts, and blurriness. Tests with data of extant and fossil material demonstrate the superior quality of RCA compared with conventional thresholding procedures, and emphasize the need for careful consideration of optimal CT scanning parameters.
Authors:
Heike Scherf; Rico Tilgner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of physical anthropology     Volume:  140     ISSN:  1096-8644     ISO Abbreviation:  Am. J. Phys. Anthropol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400654     Medline TA:  Am J Phys Anthropol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-51     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley-Liss, Inc.
Affiliation:
Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany. heike.scherf@eva.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Bone and Bones / anatomy & histology*
Femur / anatomy & histology
Fossils
Hominidae / anatomy & histology
Humans
Humerus / anatomy & histology
Imaging, Three-Dimensional
Lemur / anatomy & histology
Tomography, X-Ray Computed / methods*

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