| A new function for lactate in the toad Bufo marinus. | |
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MedLine Citation:
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PMID: 7928864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the amphibian Bufo marinus, progressive hypoxia below a critical PO2 elicits a transient 50% increase in O2 consumption that coincides with the onset of lactate formation. The present study was designed to test the hypothesis that lactate causes the observed rise in metabolic rate. Arterial bolus infusions of pH-neutral sodium lactate solutions (4 mmol/kg body wt) in toads maintained under hypoxia actually elicit a similar increase in metabolic rate. The application of adrenergic antagonists (bretylium tosylate, phentolamine, propranolol, and reserpine) inhibits this response, suggesting that catecholamines are involved. Moreover, animals injected with lactate move to a cooler environment (behavioral hypothermia), a behavioral response that is beneficial during hypoxia. We hypothesize that, in accordance with Cannon's concept of an emergency response, lactate may function as an alarm signal during hypoxia. However, the signal function of lactate is observed in animals both under hypoxia and under normoxia and should thus be considered in future studies whenever elevated lactate levels are present, e.g., during and after exercise. |
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Authors:
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H O Pörtner; L G Branco; G M Malvin; S C Wood |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 76 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-11-01 Completed Date: 1994-11-01 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2405-10 Citation Subset: IM |
Affiliation:
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Lovelace Institutes, Albuquerque, New Mexico 87108. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkalosis, Respiratory
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blood,
physiopathology Animals Behavior, Animal / drug effects, physiology Body Temperature Regulation / drug effects, physiology Bufo marinus Catecholamines / metabolism Cold Temperature Hydrogen-Ion Concentration Lactates / blood*, pharmacology Lactic Acid Oxygen Consumption / drug effects, physiology Saline Solution, Hypertonic Sympathetic Nervous System / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-38942/HL/NHLBI NIH HHS; HL-40537/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Lactates; 0/Saline Solution, Hypertonic; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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