Document Detail

A new framework for echocardiographic assessment of left ventricular mechanics: sensitivity to heart failure.
MedLine Citation:
PMID:  11093098     Owner:  NLM     Status:  MEDLINE    
A recent report describes an approach to ventricular mechanics that employs mean end-systolic fiber stress and an exact mathematical strain index based on wall thickness referenced to myocardial mass. We used echocardiography and mean arterial pressures to determine the strain index and wall stress in (1) normal hearts from patients and swine, (2) swine with pacing-induced congestive heart failure, and (3) patients with dilated cardiomyopathy. Pigs were also studied under afterload variation with phenylephrine. Paired values of stress and strain index from control hearts (both swine and human) were tightly clustered. Values from animals and patients with congestive heart failure deviated from this cluster. Excellent separation (sensitivity 83%, specificity 94%) was displayed between control and paced pigs, despite confounding effects of varying afterload. We conclude that these variables display little change over a large range of normal cardiac mass, but deviate from this range during heart failure.
S Denslow; S Balaji; K W Hewett
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  13     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-18     Completed Date:  2001-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  969-79     Citation Subset:  IM    
Division of Pediatric Cardiology, Medical University of South Carolina, Charleston, 29425, USA.
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MeSH Terms
Cardiomyopathy, Dilated / ultrasonography*
Heart Failure / ultrasonography*
Heart Ventricles / ultrasonography*
Linear Models
Sensitivity and Specificity
Ventricular Function, Left*
Erratum In:
J Am Soc Echocardiogr 2001 Feb;14(2):148

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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