| A new fluid distribution system for scale-flexible expanded bed adsorption. | |
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MedLine Citation:
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PMID: 11857279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new fluid distribution system designed for expanded bed adsorption was introduced and studied in a 150-cm diameter column. Based on fluid application through a rotating distributor, it eradicates the need for perforated plates, meshes, or local mixers. The effect of rotation rate on column performance was examined by fluidizing a 30-cm high bed of supports with tap water and introducing pulses of dye or acetone tracer. Linear bed expansion was seen as the superficial fluid velocity was raised from 170 x h(-1) to 450 cm x h(-1) (3000 L x h(-1) to 8000 L x h(-1)), and there was little change in expansion characteristics as distributor rotation rate was increased from 2.5 to 10 rpm. The distributor was observed to generate a flow pattern suitable for expanded bed adsorption when the supports were fluidized at a superficial fluid velocity of 283 cm center dot h(-1) and dye pulses introduced. At a rotation rate of 2.5 rpm, no significant dead zones were observed, and a discrete band was formed that moved up through the bed. Furthermore, the pattern of dye movement could be used to calculate interstitial linear fluid velocities of 460 cm x h(-1) and 572 cm x h(-1) at the column wall and center, respectively, indicating a parabolic flow profile. The distributor rotation rate giving the best operating conditions was found to be 2.5 rpm when the bed was fluidized at a flow velocity of 283 cm x h(-1) and the residence time distribution of acetone tracer examined. Under these conditions, the coefficient of axial dispersion was 6.1 x 10(-6) m(2) x s(-1) and 29 theoretical plates were measured. When the rotation rate was raised to 10 rpm, the coefficient of axial dispersion increased to 8.08 x 10(-6) m(2) x s(-1) and the number of theoretical plates decreased to 22. |
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Authors:
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Jürgen J Hubbuch; Anders Heebøll-Nielsen; Timothy J Hobley; Owen R T Thomas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 78 ISSN: 0006-3592 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-06 Completed Date: 2002-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 35-43 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley Periodicals, Inc. Biotechnol Bioeng 78: 35--43, 2002; DOI 10.1002/bit.10170 |
Affiliation:
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Center for Process Biotechnology, BioCentrum-DTU, Technical University of Denmark, Building 223, Søltofts Plads, DK-2800, Kgs. Lyngby, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption Chromatography, Liquid / instrumentation*, methods* Equipment Design / methods Feasibility Studies Rheology / instrumentation Rotation Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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