Document Detail

A new fabrication technique for directly coupled transmural cardiac electrodes.
MedLine Citation:
PMID:  3354705     Owner:  NLM     Status:  MEDLINE    
Many current attempts at electrophysiological elucidation of cardiac arrhythmia mechanisms have centered around activation sequence mapping. This is most commonly performed with polarized unipolar or bipolar metal electrodes, which, because of unstable direct current (DC) base-line potentials, necessitate alternating current (AC)-coupled amplification. An ideal nonpolarizable unipolar electrode offers unhindered exchange of charge allowing for stable DC recordings of biological electrical activity. In addition to activation information, DC unipolar recordings enable quantitation of systolic and diastolic potentials, other low-frequency phenomena of interest such as repolarization, as well as rapid recovery from such rapid extreme potential shifts such as defibrillation. Previous attempts to apply nonpolarizable electrodes to transmural cardiac investigations required complex wick electrode techniques to prevent mechanical movement of the fluid-metal interface when chlorided silver wire was used. We have developed a technique to fabricate miniature sintered Ag-AgCl electrodes that are mounted at various locations on a 20-gauge stainless steel needle permitting stable transmural DC unipolar electrogram recordings in vivo. The electrodes are low noise, rugged, sterilizable, and reusable and should prove useful in three-dimensional electrophysiological characterization of the heart.
F X Witkowski; P A Penkoske
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  254     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-05-12     Completed Date:  1988-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H804-10     Citation Subset:  IM    
Department of Internal Medicine, University of Alberta School of Medicine, Edmonton, Canada.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology*
Electrocardiography / instrumentation,  methods
Electrophysiology / instrumentation,  methods
Heart / physiology*,  physiopathology
Silver Compounds*
Reg. No./Substance:
0/Silver Compounds; 7440-22-4/Silver; 7783-90-6/silver chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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