| The new era of the lymphatic system: no longer secondary to the blood vascular system. | |
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MedLine Citation:
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PMID: 22474611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The blood and lymphatic systems are the two major circulatory systems in our body. Although the blood system has been studied extensively, the lymphatic system has received much less scientific and medical attention because of its elusive morphology and mysterious pathophysiology. However, a series of landmark discoveries made in the past decade has begun to change the previous misconception of the lymphatic system to be secondary to the more essential blood vascular system. In this article, we review the current understanding of the development and pathology of the lymphatic system. We hope to convince readers that the lymphatic system is no less essential than the blood circulatory system for human health and well-being. |
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Authors:
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Inho Choi; Sunju Lee; Young-Kwon Hong |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cold Spring Harbor perspectives in medicine Volume: 2 ISSN: 2157-1422 ISO Abbreviation: Cold Spring Harb Perspect Med Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-04 Completed Date: 2013-04-29 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101571139 Medline TA: Cold Spring Harb Perspect Med Country: United States |
Other Details:
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Languages: eng Pagination: a006445 Citation Subset: IM |
Affiliation:
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Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endothelial Cells / physiology* Homeodomain Proteins / metabolism Humans Lymphangiogenesis / physiology* Lymphangioleiomyomatosis / blood, pathology Lymphatic System / anatomy & histology*, cytology, embryology, metabolism, physiology* Lymphedema / drug therapy, genetics*, parasitology Receptors, Vascular Endothelial Growth Factor / metabolism Signal Transduction Tumor Suppressor Proteins / metabolism Vascular Endothelial Growth Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Tumor Suppressor Proteins; 0/Vascular Endothelial Growth Factors; 0/prospero-related homeobox 1 protein; EC 2.7.10.1/Receptors, Vascular Endothelial Growth Factor |
| Comments/Corrections | |
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