Document Detail

The new era of the lymphatic system: no longer secondary to the blood vascular system.
MedLine Citation:
PMID:  22474611     Owner:  NLM     Status:  MEDLINE    
The blood and lymphatic systems are the two major circulatory systems in our body. Although the blood system has been studied extensively, the lymphatic system has received much less scientific and medical attention because of its elusive morphology and mysterious pathophysiology. However, a series of landmark discoveries made in the past decade has begun to change the previous misconception of the lymphatic system to be secondary to the more essential blood vascular system. In this article, we review the current understanding of the development and pathology of the lymphatic system. We hope to convince readers that the lymphatic system is no less essential than the blood circulatory system for human health and well-being.
Inho Choi; Sunju Lee; Young-Kwon Hong
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-04     Completed Date:  2013-04-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  a006445     Citation Subset:  IM    
Department of Surgery, Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
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MeSH Terms
Endothelial Cells / physiology*
Homeodomain Proteins / metabolism
Lymphangiogenesis / physiology*
Lymphangioleiomyomatosis / blood,  pathology
Lymphatic System / anatomy & histology*,  cytology,  embryology,  metabolism,  physiology*
Lymphedema / drug therapy,  genetics*,  parasitology
Receptors, Vascular Endothelial Growth Factor / metabolism
Signal Transduction
Tumor Suppressor Proteins / metabolism
Vascular Endothelial Growth Factors / metabolism
Reg. No./Substance:
0/Homeodomain Proteins; 0/Tumor Suppressor Proteins; 0/Vascular Endothelial Growth Factors; 0/prospero-related homeobox 1 protein; EC, Vascular Endothelial Growth Factor

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