Document Detail


A new endothelin C-terminal analogue IBDP 064 antagonizes endothelin-3-induced cell proliferation.
MedLine Citation:
PMID:  7656997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of C-terminal linear endothelin analogues were prepared and their activities in C6 rat glioma cell line were tested. Among the synthetic analogues, IBDP 064, Fmoc-Leu-Asp-Ile-Ile-Trp-OH, was the most potent and selective inhibitor of endothelin-3-induced cell proliferation. Its action was comparable with that of the previously described peptide IRL 1038, [Cys11-Cys15]-ET-1(11-21), an ETB specific inhibitor.
Authors:
A Sedo; S Pegoraro; P Rovero; R P Revoltella
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia biologica     Volume:  41     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-02     Completed Date:  1995-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  CZECH REPUBLIC    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
Affiliation:
1st Department of Medical Chemistry and Biochemistry, 1st Medical Faculty, Charles University, Praha, Czech Republic.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Blood Proteins / pharmacology
Cell Division / drug effects*
Endothelins / pharmacology*
Fluorenes / pharmacology*
Glioma
Molecular Sequence Data
Oligopeptides / pharmacology*
Peptide Fragments / pharmacology*
Rats
Receptors, Endothelin / antagonists & inhibitors*,  metabolism
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/9-fluorenylmethoxycarbonyl-leucyl-aspartyl-isoleucyl-isoleucyl-tryptophan-OH; 0/Blood Proteins; 0/Endothelins; 0/Fluorenes; 0/Oligopeptides; 0/Peptide Fragments; 0/Receptors, Endothelin; 144602-02-8/Cys(11)-Cys(15)-endothelin-1 (11-21)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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