| A new endoluminal, flow-disrupting device for treatment of saccular aneurysms. | |
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MedLine Citation:
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PMID: 17615366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: We report a preclinical study of a new endoluminal device for aneurysm occlusion to test the hypothesis that the device, even without use of intrasaccular coil placement, could occlude saccular aneurysms without causing substantial parent artery compromise or compromise of adjacent, small branch arteries. METHODS: The Pipeline Neuroendovascular Device (Pipeline NED; Chestnut Medical Technologies, Inc) is a braided, tubular, bimetallic endoluminal implant aimed at occlusion of saccular aneurysms through flow disruption along the aneurysm neck. The device was implanted across the necks of 17 elastase-induced aneurysms in the New Zealand white rabbit model and followed for 1 month (n=6), 3 months (n=5), and 6 months (n=6). In each subject, a second device was implanted in the abdominal aorta to cover the origins of lumbar arteries. Aneurysm occlusion rates by angiography (grade 1, complete occlusion; grade 2, near-complete occlusion; and grade 3, incomplete occlusion) were documented. Percent area stenosis of the parent arteries was calculated. Presence of distal emboli in the downstream vessels in the parent artery and branch artery stenosis or occlusion was noted. RESULTS: Grades 1, 2, and 3 occlusion rates were noted in 9 (53%), 6 (35%), and 2 (12%) of 17 aneurysms, respectively, indicating an 88% rate of complete or near complete occlusion. No cases of branch artery occlusion or distal emboli in the downstream vessels of the parent artery, specifically the subclavian artery, were seen. Parent artery compromise from neointimal hyperplasia was minimal in most cases. CONCLUSIONS: The Pipeline NED is a trackable, bio- and hemocompatible device able to occlude saccular aneurysms with preservation of the parent artery and small, adjacent branch vessels. |
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Authors:
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David F Kallmes; Yong Hong Ding; Daying Dai; Ramanathan Kadirvel; Debra A Lewis; Harry J Cloft |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-05 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 38 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-31 Completed Date: 2007-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2346-52 Citation Subset: IM |
Affiliation:
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Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA. Kallmes.david@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / standards, therapeutic use Blood Pressure / physiology Cerebral Angiography Cerebral Arteries / pathology, physiopathology, radiography Cerebrovascular Circulation / physiology Cerebrovascular Disorders / etiology, physiopathology Disease Models, Animal Embolization, Therapeutic / instrumentation*, methods* Intracranial Aneurysm / physiopathology, radiography, therapy* Intracranial Embolism / etiology, physiopathology, prevention & control Prostheses and Implants / standards, trends* Rabbits Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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